Ventral frontal deficits in psychopathy: neuropsychological test findings - PubMed (original) (raw)
Ventral frontal deficits in psychopathy: neuropsychological test findings
D Lapierre et al. Neuropsychologia. 1995 Feb.
Erratum in
- Neuropsychologia 1995 Aug;33(8):1059
Abstract
The hypothesis of prefrontal dysfunction in psychopathy has been pursued for many years, without convincing results. It is proposed here that this approach in previous studies was far too global. The present investigation was carried out in order to test a more specific hypothesis of orbitofrontal and/or frontal ventromedial deficits in psychopathy. Psychopathic criminals were compared to non-psychopathic criminals with measures related to orbitofrontal or frontal ventromedial functioning, as well as with control measures more associated with frontodorsolateral and posterorolandic functions. All subjects provided urine samples for drug assay. It was found that, while the two groups performed similarly on all the control measures, including the drug tests, the psychopaths were significantly impaired on all the orbitofrontal-ventromedial tasks. The psychopaths were significantly impulsive on several tests as well as significantly dysosmic [corrected]. The latter finding is particularly important in the sense that it cannot readily be explained socioculturally, thus presenting a new and convincing argument for brain-based etiology of this disorder. The results are discussed in relation to other psychiatric disorders characterized by impulse dyscontrol as well as in relation to other putative neurobiological etiological factors in psychopathy.
Similar articles
- [From conduct disorder in childhood to psychopathy in adult life].
Tsopelas Ch, Armenaka M. Tsopelas Ch, et al. Psychiatriki. 2012 Jun;23 Suppl 1:107-16. Psychiatriki. 2012. PMID: 22796980 Review. Greek, Modern. - The role of the orbitofrontal cortex in affective theory of mind deficits in criminal offenders with psychopathic tendencies.
Shamay-Tsoory SG, Harari H, Aharon-Peretz J, Levkovitz Y. Shamay-Tsoory SG, et al. Cortex. 2010 May;46(5):668-77. doi: 10.1016/j.cortex.2009.04.008. Epub 2009 May 18. Cortex. 2010. PMID: 19501818 - Differentiating among prefrontal substrates in psychopathy: neuropsychological test findings.
Blair KS, Newman C, Mitchell DGV, Richell RA, Leonard A, Morton J, Blair RJR. Blair KS, et al. Neuropsychology. 2006 Mar;20(2):153-165. doi: 10.1037/0894-4105.20.2.153. Neuropsychology. 2006. PMID: 16594776 - Functional Connectivity Bias in the Prefrontal Cortex of Psychopaths.
Contreras-Rodríguez O, Pujol J, Batalla I, Harrison BJ, Soriano-Mas C, Deus J, López-Solà M, Macià D, Pera V, Hernández-Ribas R, Pifarré J, Menchón JM, Cardoner N. Contreras-Rodríguez O, et al. Biol Psychiatry. 2015 Nov 1;78(9):647-55. doi: 10.1016/j.biopsych.2014.03.007. Epub 2014 Mar 14. Biol Psychiatry. 2015. PMID: 24742618
Cited by
- Neural Correlates of Psychopathic Traits in Schizophrenia: fMRI Study of Response Inhibition in Persistently Violent Patients.
Krakowski MI, Hoptman MJ, Czobor P. Krakowski MI, et al. Schizophr Bull Open. 2023 Mar 23;4(1):sgad009. doi: 10.1093/schizbullopen/sgad009. eCollection 2023 Jan. Schizophr Bull Open. 2023. PMID: 39145336 Free PMC article. - Identifying distinct profiles of impulsivity for the four facets of psychopathy.
West SJ, Psederska E, Bozgunov K, Nedelchev D, Vasilev G, Thomson ND, Vassileva J. West SJ, et al. PLoS One. 2023 Apr 14;18(4):e0283866. doi: 10.1371/journal.pone.0283866. eCollection 2023. PLoS One. 2023. PMID: 37058489 Free PMC article. - Neurocognitive functions of prosocial and unsocial incongruency information during language comprehension: evidence from time-frequency analysis of EEG signals.
Tarai S, Qurratul QA, Ratre V, Bit A. Tarai S, et al. Med Biol Eng Comput. 2022 Apr;60(4):1033-1053. doi: 10.1007/s11517-022-02528-w. Epub 2022 Feb 24. Med Biol Eng Comput. 2022. PMID: 35201573 - Alcohol, Aggression, and Violence: From Public Health to Neuroscience.
Sontate KV, Rahim Kamaluddin M, Naina Mohamed I, Mohamed RMP, Shaikh MF, Kamal H, Kumar J. Sontate KV, et al. Front Psychol. 2021 Dec 20;12:699726. doi: 10.3389/fpsyg.2021.699726. eCollection 2021. Front Psychol. 2021. PMID: 35002823 Free PMC article. Review. - Effects of Psychopathy on Neurocognitive Domains of Impulsivity in Abstinent Opiate and Stimulant Users.
Psederska E, Thomson ND, Bozgunov K, Nedelchev D, Vasilev G, Vassileva J. Psederska E, et al. Front Psychiatry. 2021 Jun 9;12:660810. doi: 10.3389/fpsyt.2021.660810. eCollection 2021. Front Psychiatry. 2021. PMID: 34177649 Free PMC article.