Enhancing the effectiveness of relaxation-thermal biofeedback training with propranolol hydrochloride - PubMed (original) (raw)
Clinical Trial
Enhancing the effectiveness of relaxation-thermal biofeedback training with propranolol hydrochloride
K A Holroyd et al. J Consult Clin Psychol. 1995 Apr.
Abstract
This article evaluated the ability of propranolol to enhance results achieved with relaxation-biofeedback training. Thirty-three patients were randomized to relaxation-biofeedback training alone (administered in a limited-contact treatment format), or to relaxation-biofeedback training accompanied by long-acting propranolol (with dosage individualized at 60, 120, or 180 mg/day). Concomitant propranolol therapy significantly enhanced the effectiveness of relaxation-biofeedback training when either daily headache recordings (79% vs. 54% reduction in migraine activity) or neurologist clinical evaluations (90% vs. 66% reduction) were used to assess treatment outcome. Concomitant propranolol therapy also yielded larger reductions in analgesic medication use and greater improvements of quality of life measures than relaxation-biofeedback training alone but was more frequently associated with side effects.
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