Integrins and other adhesion molecules involved in melanocytic tumor progression - PubMed (original) (raw)

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Integrins and other adhesion molecules involved in melanocytic tumor progression

M Edward. Curr Opin Oncol. 1995 Mar.

Abstract

Recent investigations have reported changes in the expression of cell surface adhesion molecules associated with melanoma progression from in situ to invasive to metastatic tumors, including the upregulation of the integrins alpha v beta 3, alpha 3 beta 1, alpha 4 beta 1, and alpha 5 beta 1, downregulation of alpha 6 beta 1, and enhanced expression of intercellular adhesion molecule-1, MUC18, and CD44. Current research is now focused on the function of these adhesion molecules in facilitating melanoma invasion, metastasis and evasion of lysis by effector cells, and the mechanisms involved in controlling the adhesion molecule activation state and signal transduction.

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Comment in

• Melanoma and other skin neoplasms.
  MacKie RM, Guerry D 4th. MacKie RM, et al. Curr Opin Oncol. 1995 Mar;7(2):159-61. doi: 10.1097/00001622-199503000-00011. Curr Opin Oncol. 1995. PMID: 7756381 No abstract available.

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