G beta gamma interactions with PH domains and Ras-MAPK signaling pathways - PubMed (original) (raw)
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G beta gamma interactions with PH domains and Ras-MAPK signaling pathways
J Inglese et al. Trends Biochem Sci. 1995 Apr.
Abstract
G-protein-coupled receptor signaling and receptor tyrosine kinase (RTK) signaling are two mechanisms of transmembrane communication used by numerous extracellular agents and stimuli. The beta gamma-subunit complex of G proteins mediates many of the functions associated with G-protein-coupled receptor signaling and may even provide a means to link G proteins to RTK-initiated cascades. This connection may be mediated by the pleckstrin homology domain, a modular domain found in many signaling proteins that interact with G beta gamma.
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