Interleukin-1 beta converting enzyme: a novel cysteine protease required for IL-1 beta production and implicated in programmed cell death - PubMed (original) (raw)
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Interleukin-1 beta converting enzyme: a novel cysteine protease required for IL-1 beta production and implicated in programmed cell death
N A Thornberry et al. Protein Sci. 1995 Jan.
Abstract
Interleukin-1 beta converting enzyme is the first member of a new class of cysteine proteases. The most distinguishing feature of this family is a nearly absolute specificity for cleavage at aspartic acid. This enzyme has been the subject of intense research because of its role in the production of IL-1 beta, a key mediator of inflammation. These studies have culminated in the design of potent inhibitors and determination of its crystal structure. The structure secures the relationship of the enzyme to CED-3, the product of a gene required for programmed cell death in Caenorhabditis elegans, suggesting that members of this family function in cell death in vertebrates.
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References
- Cell. 1993 Nov 19;75(4):641-52 - PubMed
- Ann N Y Acad Sci. 1993 Nov 30;696:133-48 - PubMed
- Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1809-13 - PubMed
- Science. 1992 Dec 18;258(5090):1955-7 - PubMed
- J Med Chem. 1990 Jan;33(1):11-3 - PubMed
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