Telomerase activity associated with acquisition of malignancy in human colorectal cancer - PubMed (original) (raw)
Comparative Study
. 1995 Jun 15;55(12):2533-6.
Affiliations
- PMID: 7780964
Comparative Study
Telomerase activity associated with acquisition of malignancy in human colorectal cancer
C Chadeneau et al. Cancer Res. 1995.
Abstract
Shortening of telomeres may contribute to the control of the proliferative capacity of normal cells, and telomerase, the enzyme that elongates telomeric DNA, may be essential for unlimited cell proliferation. We have shown previously that telomerase activity is present in human cells immortalized in vitro and in metastatic ovarian carcinoma cells but is undetectable in normal cultured cells or normal tissues. We have determined the temporal pattern of telomerase activity during colorectal carcinogenesis in man. We report that telomerase activity is associated with acquisition of malignancy as it is detectable in colorectal carcinoma but not in adenomatous polyps. Mutations leading to reactivation or upregulation of the enzyme may represent an additional required event in the multistep development of colorectal cancer.
Similar articles
- Telomerase and telomere length in the development and progression of premalignant lesions to colorectal cancer.
Engelhardt M, Drullinsky P, Guillem J, Moore MA. Engelhardt M, et al. Clin Cancer Res. 1997 Nov;3(11):1931-41. Clin Cancer Res. 1997. PMID: 9815582 - Change in telomerase activity during human colorectal carcinogenesis.
Yoshida R, Kiyozuka Y, Ichiyoshi H, Senzaki H, Takada H, Hioki K, Tsubura A. Yoshida R, et al. Anticancer Res. 1999 May-Jun;19(3B):2167-72. Anticancer Res. 1999. PMID: 10472326 - Evaluation of telomerase in the development and progression of colon cancer.
Boldrini L, Faviana P, Gisfredi S, Zucconi Y, Di Quirico D, Donati V, Berti P, Spisni R, Galleri D, Materazzi G, Basolo F, Miccoli P, Pingitore R, Fontanini G. Boldrini L, et al. Int J Mol Med. 2002 Nov;10(5):589-92. Int J Mol Med. 2002. PMID: 12373297 - Differential activation of total and EGF receptor (EGF-R) tyrosine kinase (tyr-k) in the rectal mucosa in patients with adenomatous polyps, ulcerative colitis and colon cancer.
Malecka-Panas E, Kordek R, Biernat W, Tureaud J, Liberski PP, Majumdar AP. Malecka-Panas E, et al. Hepatogastroenterology. 1997 Mar-Apr;44(14):435-40. Hepatogastroenterology. 1997. PMID: 9164515 - High telomerase activity is an independent prognostic indicator of poor outcome in colorectal cancer.
Tatsumoto N, Hiyama E, Murakami Y, Imamura Y, Shay JW, Matsuura Y, Yokoyama T. Tatsumoto N, et al. Clin Cancer Res. 2000 Jul;6(7):2696-701. Clin Cancer Res. 2000. PMID: 10914712
Cited by
- Telomeres and telomerase in the clinical management of colorectal cancer.
Piñol-Felis C, Fernández-Marcelo T, Viñas-Salas J, Valls-Bautista C. Piñol-Felis C, et al. Clin Transl Oncol. 2017 Apr;19(4):399-408. doi: 10.1007/s12094-016-1559-0. Epub 2016 Oct 19. Clin Transl Oncol. 2017. PMID: 27761787 Review. - Hyperbaric oxygen therapy for malignancy: a review.
Daruwalla J, Christophi C. Daruwalla J, et al. World J Surg. 2006 Dec;30(12):2112-31. doi: 10.1007/s00268-006-0190-6. World J Surg. 2006. PMID: 17102915 Review. - The expression of hTR and hTERT in human breast cancer: correlation with clinico-pathological parameters.
Hosseini-Asl S, Atri M, Modarressi MH, Salhab M, Mokbel K, Mehdipour P. Hosseini-Asl S, et al. Int Semin Surg Oncol. 2006 Aug 22;3:20. doi: 10.1186/1477-7800-3-20. Int Semin Surg Oncol. 2006. PMID: 16925810 Free PMC article. - Gene expression for suppressors of telomerase activity (telomeric-repeat binding factors) in breast cancer.
Saito K, Yagihashi A, Nasu S, Izawa Y, Nakamura M, Kobayashi D, Tsuji N, Watanabe N. Saito K, et al. Jpn J Cancer Res. 2002 Mar;93(3):253-8. doi: 10.1111/j.1349-7006.2002.tb02166.x. Jpn J Cancer Res. 2002. PMID: 11927006 Free PMC article. - Telomerase activity in chronic inflammatory bowel disease.
Kleideiter E, Friedrich U, Möhring A, Walker S, Höring E, Maier K, Fritz P, Thon KP, Klotz U. Kleideiter E, et al. Dig Dis Sci. 2003 Dec;48(12):2328-32. doi: 10.1023/b:ddas.0000007871.86129.4a. Dig Dis Sci. 2003. PMID: 14714621
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Medical