The survival and turnover of mature and immature CD8 T cells - PubMed (original) (raw)

The survival and turnover of mature and immature CD8 T cells

M McDonagh et al. Immunology. 1995 Apr.

Abstract

The present investigation has examined the phenotype, survival and fate of immature and mature CD8 T cells. CD4- CD8+ 'single positive' thymocytes (a model for recent thymic emigrants) were Thy-1+ CD45RC- RT6- before transfer to normal euthymic recipients, but changed phenotype within 7-10 days to become Thy-1- CD45RC+ RT6(+)--the phenotype of mature resting CD8 T cells. Following transfer to athymic nude recipients CD8 T cells from thoracic duct lymph of allotype-marked rats increased 12-17-fold during the first 2 months. Proliferation occurred in the complete absence of CD4 T cells and the donor CD8 T cells persisted [at 15-18% of peripheral blood lymphocytes (PBL)] for the life of the recipients. When combined with equal numbers of CD4 T cells, however, CD8 T cells occupied only 3-4% of PBL; in these animals CD4 T cells plateaued at 15-16% of PBL. The results suggested that CD8 T cells competed poorly with rapidly dividing CD4 T cells for limited space in a recirculating pool in which total T-cell numbers are homeostatically regulated. Although able to proliferate and self-renew in athymic nude recipients, when transferred to normal euthymic animals donor-derived mature CD8 T cells declined in number with time; their half-life was estimated to be 34 days. Similar studies with purified CD4- CD8+ 'single positive' thymocytes gave a comparable half-life of 37 days. The results indicated that lifespan was not due to an ageing process among CD8 T cells, but was rather a reflection of cell turnover dependent on thymic output.

PubMed Disclaimer

Cited by

Early pediatric atopic dermatitis shows only a cutaneous lymphocyte antigen (CLA)(+) TH2/TH1 cell imbalance, whereas adults acquire CLA(+) TH22/TC22 cell subsets.
Czarnowicki T, Esaki H, Gonzalez J, Malajian D, Shemer A, Noda S, Talasila S, Berry A, Gray J, Becker L, Estrada Y, Xu H, Zheng X, Suárez-Fariñas M, Krueger JG, Paller AS, Guttman-Yassky E. Czarnowicki T, et al. J Allergy Clin Immunol. 2015 Oct;136(4):941-951.e3. doi: 10.1016/j.jaci.2015.05.049. Epub 2015 Aug 1. J Allergy Clin Immunol. 2015. PMID: 26242300 Free PMC article.
Optimizing antiviral therapy for COVID-19 with learned pathogenic model.
Dutta A. Dutta A. Sci Rep. 2022 Apr 27;12(1):6873. doi: 10.1038/s41598-022-10929-y. Sci Rep. 2022. PMID: 35477965 Free PMC article.
B cells regulate thymic CD8+T cell differentiation in lupus-prone mice.
Xing C, Zhu G, Xiao H, Fang Y, Liu X, Han G, Chen G, Hou C, Shen B, Li Y, Ma N, Wang R. Xing C, et al. Oncotarget. 2017 Jul 5;8(52):89486-89499. doi: 10.18632/oncotarget.19002. eCollection 2017 Oct 27. Oncotarget. 2017. PMID: 29163765 Free PMC article.
A central role for thymic emigrants in peripheral T cell homeostasis.
Berzins SP, Godfrey DI, Miller JF, Boyd RL. Berzins SP, et al. Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9787-91. doi: 10.1073/pnas.96.17.9787. Proc Natl Acad Sci U S A. 1999. PMID: 10449772 Free PMC article.
Activation-induced inhibition of interleukin 6-mediated T cell survival and signal transducer and activator of transcription 1 signaling.
Teague TK, Schaefer BC, Hildeman D, Bender J, Mitchell T, Kappler JW, Marrack P. Teague TK, et al. J Exp Med. 2000 Mar 20;191(6):915-26. doi: 10.1084/jem.191.6.915. J Exp Med. 2000. PMID: 10727454 Free PMC article.

References

1. Nature. 1985 Oct 31-Nov 6;317(6040):811-3 - PubMed
1. Scand J Immunol. 1985 Aug;22(2):157-69 - PubMed
1. Nature. 1986 Aug 28-Sep 3;322(6082):829-31 - PubMed
1. J Immunol. 1987 Sep 1;139(5):1379-84 - PubMed
1. Mol Immunol. 1987 Dec;24(12):1281-90 - PubMed

The survival and turnover of mature and immature CD8 T cells - PubMed (original) (raw)