Glial swelling in ischemia: a hypothesis - PubMed (original) (raw)
Review
Glial swelling in ischemia: a hypothesis
W Walz et al. Dev Neurosci. 1993.
Abstract
On the basis of experiments with primary cultures of mouse astrocytes with conventional K(+)-sensitive intracellular microelectrodes involving 'chemical ischemia' (antimycin a and sodium fluoride treatment), a model of ischemia is presented. According to this model, ischemia has no significant direct effect during the first 10 min on astrocytes; neurones, however, lose a major part of their K+ into the ECS. This leads to an astrocytic depolarization, which in turn activates astrocytic anion channels. This will result in passive, Donnan-mediated K+, Cl- and HCO3- fluxes into astrocytes, which in turn causes swelling and a collapse of the ECS. Arguments are put forward that this may explain the swelling of astrocytic endfeet, which occurs very early in an ischemic insult.
Similar articles
- Role of astrocytes in the spreading depression signal between ischemic core and penumbra.
Walz W. Walz W. Neurosci Biobehav Rev. 1997 Mar;21(2):135-42. doi: 10.1016/s0149-7634(96)00003-6. Neurosci Biobehav Rev. 1997. PMID: 9062936 Review. - Astrocytic swelling in cerebral ischemia as a possible cause of injury and target for therapy.
Kimelberg HK. Kimelberg HK. Glia. 2005 Jun;50(4):389-397. doi: 10.1002/glia.20174. Glia. 2005. PMID: 15846797 Review. - Astrocyte ERK phosphorylation precedes K(+)-induced swelling but follows hypotonicity-induced swelling.
Cai L, Du T, Song D, Li B, Hertz L, Peng L. Cai L, et al. Neuropathology. 2011 Jun;31(3):250-64. doi: 10.1111/j.1440-1789.2010.01172.x. Epub 2010 Dec 1. Neuropathology. 2011. PMID: 21118399 - Transformation of postischemic perineuronal glial cells. I. Electron microscopic studies.
Petito CK. Petito CK. J Cereb Blood Flow Metab. 1986 Oct;6(5):616-24. doi: 10.1038/jcbfm.1986.109. J Cereb Blood Flow Metab. 1986. PMID: 3760046 - Use of cell cultures to differentiate among effects of various ischemia factors on astrocytic cell volume.
Juurlink BH, Chen Y, Hertz L. Juurlink BH, et al. Can J Physiol Pharmacol. 1992;70 Suppl:S344-9. doi: 10.1139/y92-281. Can J Physiol Pharmacol. 1992. PMID: 1363533
Cited by
- Astrocyte-Neuronal Communication and Its Role in Stroke.
Yao ZM, Sun XR, Huang J, Chen L, Dong SY. Yao ZM, et al. Neurochem Res. 2023 Oct;48(10):2996-3006. doi: 10.1007/s11064-023-03966-0. Epub 2023 Jun 17. Neurochem Res. 2023. PMID: 37329448 Review. - Role of astrocytes in pathogenesis of ischemic brain injury.
Gabryel B, Trzeciak HI. Gabryel B, et al. Neurotox Res. 2001 Apr;3(2):205-21. doi: 10.1007/BF03033192. Neurotox Res. 2001. PMID: 14715474 - "No-reflow" phenomenon in acute ischemic stroke.
Zhang Y, Jiang M, Gao Y, Zhao W, Wu C, Li C, Li M, Wu D, Wang W, Ji X. Zhang Y, et al. J Cereb Blood Flow Metab. 2024 Jan;44(1):19-37. doi: 10.1177/0271678X231208476. Epub 2023 Oct 19. J Cereb Blood Flow Metab. 2024. PMID: 37855115 Free PMC article. Review. - Anion conductance behavior of the glutamate uptake carrier in salamander retinal glial cells.
Billups B, Rossi D, Attwell D. Billups B, et al. J Neurosci. 1996 Nov 1;16(21):6722-31. doi: 10.1523/JNEUROSCI.16-21-06722.1996. J Neurosci. 1996. PMID: 8824313 Free PMC article. - Neuroprotective Mechanisms of Taurine against Ischemic Stroke.
Menzie J, Prentice H, Wu JY. Menzie J, et al. Brain Sci. 2013 Jun 3;3(2):877-907. doi: 10.3390/brainsci3020877. Brain Sci. 2013. PMID: 24961429 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources