Genomic structure, promoter sequence, and revised translation of human homeobox gene HLX1 - PubMed (original) (raw)
Comparative Study
. 1994 Jul 15;22(2):348-55.
doi: 10.1006/geno.1994.1394.
Affiliations
- PMID: 7806220
- DOI: 10.1006/geno.1994.1394
Comparative Study
Genomic structure, promoter sequence, and revised translation of human homeobox gene HLX1
M A Kennedy et al. Genomics. 1994.
Abstract
The human homeobox gene HLX1 appears to be involved in hemopoietic development and may represent a candidate gene for various developmental or hemopoietic disorders. We have isolated genomic clones for the gene, determined its intron-exon organization, and confirmed its map location on chromosome 1q41-q42. The transcription initiation sites of HLX1 were identified, and DNA sequences upstream of these sites were established. Finally, several differences between the genomic sequence and the published cDNA sequence were noted. Translation based on this revised sequence gives rise to a putative protein with 86.5% homology to the product of the murine Hlx gene.
Similar articles
- A novel epithelial-expressed ETS gene, ELF3: human and murine cDNA sequences, murine genomic organization, human mapping to 1q32.2 and expression in tissues and cancer.
Tymms MJ, Ng AY, Thomas RS, Schutte BC, Zhou J, Eyre HJ, Sutherland GR, Seth A, Rosenberg M, Papas T, Debouck C, Kola I. Tymms MJ, et al. Oncogene. 1997 Nov 13;15(20):2449-62. doi: 10.1038/sj.onc.1201427. Oncogene. 1997. PMID: 9395241 - Linkage localization of TGFB2 and the human homeobox gene HLX1 to chromosome 1q.
Nishimura DY, Purchio AF, Murray JC. Nishimura DY, et al. Genomics. 1993 Feb;15(2):357-64. doi: 10.1006/geno.1993.1068. Genomics. 1993. PMID: 8095486 - Homeodomain proteins.
Gehring WJ, Affolter M, Bürglin T. Gehring WJ, et al. Annu Rev Biochem. 1994;63:487-526. doi: 10.1146/annurev.bi.63.070194.002415. Annu Rev Biochem. 1994. PMID: 7979246 Review. No abstract available. - Tissue factor regulation and gene organization.
Morrissey JH, Gregory SA, Mackman N, Edgington TS. Morrissey JH, et al. Oxf Surv Eukaryot Genes. 1989;6:67-84. Oxf Surv Eukaryot Genes. 1989. PMID: 2698632 Review. No abstract available.
Cited by
- H2.0-like homeobox 1 acts as a tumor suppressor in hepatocellular carcinoma.
Liu T, Chen J, Xiao S, Lei X. Liu T, et al. Tumour Biol. 2016 May;37(5):6419-28. doi: 10.1007/s13277-015-4490-z. Epub 2015 Dec 2. Tumour Biol. 2016. PMID: 26631039 - Transcriptional repression by the Caenorhabditis elegans germ-line protein PIE-1.
Batchelder C, Dunn MA, Choy B, Suh Y, Cassie C, Shim EY, Shin TH, Mello C, Seydoux G, Blackwell TK. Batchelder C, et al. Genes Dev. 1999 Jan 15;13(2):202-12. doi: 10.1101/gad.13.2.202. Genes Dev. 1999. PMID: 9925644 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Research Materials