Ablation of islet endocrine cells by targeted expression of hormone-promoter-driven toxigenes - PubMed (original) (raw)

Ablation of islet endocrine cells by targeted expression of hormone-promoter-driven toxigenes

P L Herrera et al. Proc Natl Acad Sci U S A. 1994.

Abstract

Ontogenic relationships between the different types of endocrine cells in the islets of Langerhans were explored by generating transgenic mouse embryos in which cells transcribing the glucagon, insulin, or pancreatic polypeptide genes were destroyed through the promoter-targeted expression of the diphtheria toxin A chain. Embryos lacking glucagon- or insulin-containing cells did not exhibit alterations in the development of the nontargeted islet cell types, whereas embryos lacking pancreatic polypeptide gene-expressing cells also lacked pancreatic insulin- and somatostatin-containing cells. These results show that neither glucagon nor insulin gene-expressing cells are essential for the differentiation of the other islet endocrine-cell types. These results also suggest that pancreatic polypeptide gene-expressing cells are indispensable for the differentiation of islet beta and delta cells because the former produce a necessary paracrine or endocrine factor and/or operate through a cell-lineage relationship.

PubMed Disclaimer

Similar articles

• Two transgenic approaches to define the cell lineages in endocrine pancreas development.
  Herrera PL, Orci L, Vassalli JD. Herrera PL, et al. Mol Cell Endocrinol. 1998 May 25;140(1-2):45-50. doi: 10.1016/s0303-7207(98)00028-8. Mol Cell Endocrinol. 1998. PMID: 9722167
• Single pancreatic beta cells co-express multiple islet hormone genes in mice.
  Katsuta H, Akashi T, Katsuta R, Nagaya M, Kim D, Arinobu Y, Hara M, Bonner-Weir S, Sharma AJ, Akashi K, Weir GC. Katsuta H, et al. Diabetologia. 2010 Jan;53(1):128-38. doi: 10.1007/s00125-009-1570-x. Epub 2009 Oct 23. Diabetologia. 2010. PMID: 19851748 Free PMC article.
• Development of pancreatic islets in pancreatic polypeptide-overexpressing mice.
  Yuzuriha H, Inui A, Asakawa A, Ueno N, Sakamaki R, Shinfuku N, Kasuga M, Fujimiya M. Yuzuriha H, et al. Int J Mol Med. 2004 Aug;14(2):201-5. Int J Mol Med. 2004. PMID: 15254766
• On the origin of pancreatic endocrine cells, proliferation and neoplastic transformation.
  Teitelman G. Teitelman G. Tumour Biol. 1993;14(3):167-73. doi: 10.1159/000217832. Tumour Biol. 1993. PMID: 8210949 Review.
• Defining the cell lineages of the islets of Langerhans using transgenic mice.
  Herrera PL. Herrera PL. Int J Dev Biol. 2002 Jan;46(1):97-103. Int J Dev Biol. 2002. PMID: 11902693 Review.

Cited by

• Regulated and adaptive in vivo insulin secretion from islets only containing β-cells.
  Perez-Frances M, Bru-Tari E, Cohrs C, Abate MV, van Gurp L, Furuyama K, Speier S, Thorel F, Herrera PL. Perez-Frances M, et al. Nat Metab. 2024 Sep;6(9):1791-1806. doi: 10.1038/s42255-024-01114-8. Epub 2024 Aug 21. Nat Metab. 2024. PMID: 39169271 Free PMC article.
• Effective Generation of Functional Pancreatic β Cells from Human-Derived Dental Stem Cells of Apical Papilla and Bone-Marrow-Derived Stem Cells: A Comparative Study.
  Abuarqoub D, Adwan S, Zaza R, Wehaibi S, Aslam N, Jafar H, Qinnah N, Awidi A. Abuarqoub D, et al. Pharmaceuticals (Basel). 2023 Apr 26;16(5):649. doi: 10.3390/ph16050649. Pharmaceuticals (Basel). 2023. PMID: 37242432 Free PMC article.
• Generation of human islet cell type-specific identity genesets.
  van Gurp L, Fodoulian L, Oropeza D, Furuyama K, Bru-Tari E, Vu AN, Kaddis JS, Rodríguez I, Thorel F, Herrera PL. van Gurp L, et al. Nat Commun. 2022 Apr 19;13(1):2020. doi: 10.1038/s41467-022-29588-8. Nat Commun. 2022. PMID: 35440614 Free PMC article.
• Adult pancreatic islet endocrine cells emerge as fetal hormone-expressing cells.
  Perez-Frances M, Abate MV, Baronnier D, Scherer PE, Fujitani Y, Thorel F, Herrera PL. Perez-Frances M, et al. Cell Rep. 2022 Feb 15;38(7):110377. doi: 10.1016/j.celrep.2022.110377. Cell Rep. 2022. PMID: 35172145 Free PMC article.
• Characterisation of Ppy-lineage cells clarifies the functional heterogeneity of pancreatic beta cells in mice.
  Fukaishi T, Nakagawa Y, Fukunaka A, Sato T, Hara A, Nakao K, Saito M, Kohno K, Miyatsuka T, Tamaki M, Matsuhisa M, Matsuoka TA, Yamada T, Watada H, Fujitani Y. Fukaishi T, et al. Diabetologia. 2021 Dec;64(12):2803-2816. doi: 10.1007/s00125-021-05560-x. Epub 2021 Sep 9. Diabetologia. 2021. PMID: 34498099 Free PMC article.

References

1. 1. Dev Biol. 1968 Apr;17(4):413-46 - PubMed
2. 1. Development. 1994 Feb;120(2):245-52 - PubMed
3. 1. Circ Res. 1980 Jul;47(1):1-9 - PubMed
4. 1. Peptides. 1981;2 Suppl 2:157-68 - PubMed
5. 1. Diabetes. 1982 Jun;31(6 Pt 1):538-65 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Europe PubMed Central
  • PubMed Central

• Other Literature Sources

  • The Lens - Patent Citations