Anti-diabetic activity present in the fruit body of Grifola frondosa (Maitake). I - PubMed (original) (raw)
. 1994 Aug;17(8):1106-10.
doi: 10.1248/bpb.17.1106.
Affiliations
- PMID: 7820117
- DOI: 10.1248/bpb.17.1106
Free article
Anti-diabetic activity present in the fruit body of Grifola frondosa (Maitake). I
K Kubo et al. Biol Pharm Bull. 1994 Aug.
Free article
Abstract
The fruit body of Grifola frondosa (maitake), Basidiomycetes was confirmed to contain substances with anti-diabetic activity. When 1 g/d of powdered fruit body of maitake was given orally to a genetically diabetic mouse (KK-Ay), blood glucose reduction was observed, in contrast to the control group in which the blood glucose increased with ageing. Moreover, levels of insulin and triglyceride in plasma demonstrated a change similar to blood glucose with feeding of maitake. Ether-ethanol-soluble (ES) and hot water-soluble (WS) fractions were prepared from the fruit body and their hypoglycemic activity was examined. Blood glucose-lowering activity was found when ES-fraction or WS-50% ethanol float (X) fraction was administered orally, but other WS-fractions were inactive. These results suggest that the anti-diabetic activity was present not only in the ES-fraction consisting of lipid but also in the X-fraction of peptidoglycan (sugar:protein = 65:35).
Similar articles
- Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains.
Talpur NA, Echard BW, Fan AY, Jaffari O, Bagchi D, Preuss HG. Talpur NA, et al. Mol Cell Biochem. 2002 Aug;237(1-2):129-36. doi: 10.1023/a:1016503804742. Mol Cell Biochem. 2002. PMID: 12236580 - Anti-diabetic effect of an alpha-glucan from fruit body of maitake (Grifola frondosa) on KK-Ay mice.
Hong L, Xun M, Wutong W. Hong L, et al. J Pharm Pharmacol. 2007 Apr;59(4):575-82. doi: 10.1211/jpp.59.4.0013. J Pharm Pharmacol. 2007. PMID: 17430642 - Maitake (Grifola frondosa) improve glucose tolerance of experimental diabetic rats.
Horio H, Ohtsuru M. Horio H, et al. J Nutr Sci Vitaminol (Tokyo). 2001 Feb;47(1):57-63. doi: 10.3177/jnsv.47.57. J Nutr Sci Vitaminol (Tokyo). 2001. PMID: 11349892 - Hypoglycemic effect of hot-water extract of adzuki (Vigna angularis) in spontaneously diabetic KK-A(y) mice.
Itoh T, Kobayashi M, Horio F, Furuichi Y. Itoh T, et al. Nutrition. 2009 Feb;25(2):134-41. doi: 10.1016/j.nut.2008.08.001. Epub 2008 Oct 16. Nutrition. 2009. PMID: 18929464 - Unveiling the full spectrum of maitake mushrooms: A comprehensive review of their medicinal, therapeutic, nutraceutical, and cosmetic potential.
Camilleri E, Blundell R, Baral B, Karpiński TM, Aruci E, Atrooz OM. Camilleri E, et al. Heliyon. 2024 Apr 26;10(9):e30254. doi: 10.1016/j.heliyon.2024.e30254. eCollection 2024 May 15. Heliyon. 2024. PMID: 38707308 Free PMC article. Review.
Cited by
- A polysaccharide from Grifola frondosa relieves insulin resistance of HepG2 cell by Akt-GSK-3 pathway.
Ma X, Zhou F, Chen Y, Zhang Y, Hou L, Cao X, Wang C. Ma X, et al. Glycoconj J. 2014 Jul;31(5):355-63. doi: 10.1007/s10719-014-9526-x. Epub 2014 Jun 8. Glycoconj J. 2014. PMID: 24908430 - Antitumor activity of orally administered maitake α-glucan by stimulating antitumor immune response in murine tumor.
Masuda Y, Nakayama Y, Tanaka A, Naito K, Konishi M. Masuda Y, et al. PLoS One. 2017 Mar 9;12(3):e0173621. doi: 10.1371/journal.pone.0173621. eCollection 2017. PLoS One. 2017. PMID: 28278221 Free PMC article. - Medicinal mushroom: boon for therapeutic applications.
Chaturvedi VK, Agarwal S, Gupta KK, Ramteke PW, Singh MP. Chaturvedi VK, et al. 3 Biotech. 2018 Aug;8(8):334. doi: 10.1007/s13205-018-1358-0. Epub 2018 Jul 23. 3 Biotech. 2018. PMID: 30073119 Free PMC article. Review. - Synergistic potentiation of D-fraction with vitamin C as possible alternative approach for cancer therapy.
Konno S. Konno S. Int J Gen Med. 2009 Jul 30;2:91-108. doi: 10.2147/ijgm.s5498. Int J Gen Med. 2009. PMID: 20360893 Free PMC article. - Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains.
Talpur NA, Echard BW, Fan AY, Jaffari O, Bagchi D, Preuss HG. Talpur NA, et al. Mol Cell Biochem. 2002 Aug;237(1-2):129-36. doi: 10.1023/a:1016503804742. Mol Cell Biochem. 2002. PMID: 12236580
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical