Idiopathic late-onset immunoglobulin deficiency. Clinical observations in 50 patients - PubMed (original) (raw)
Review
Idiopathic late-onset immunoglobulin deficiency. Clinical observations in 50 patients
P E Hermans et al. Am J Med. 1976 Aug.
Abstract
Fifty patients with late-onset idiopathic immunoglobulin deficiency were studied and the frequency of various clinical associations and complications was observed. Men and women were equally affected, although the age at onset in men peaked in the third decade whereas it was more uniformly distributed in women. Sinobronchopulmonary infections were common and were caused by Haemophilus influenzae. Diplococcus pneumoniae, Streptococcus pyogenes and Staphylococcus aureus: bronchiectasis occurred in 28 per cent. Thirty patients (60 per cent) had diarrhea, which was often associated with steatorrhea, giardiasis, achlorhydria, abnormal Schilling tests and morphologic abnormalities on small bowel biopsy specimens, including nodular lymphoid hyperplasia; three patients had pernicious anemia. In the 20 patients without diarrhea these abnormalities were not observed except for giardiasis in one patient and achlorhydria in two patients. Cholelithiasis occurred in both groups in about a third of the patients tested. A high degree of susceptibility to neoplasia was noted. Thyroid abnormalities, including primary hypothyroidism and Graves' disease, were observed in six patients. Additional occasional findings were vitiligo, keratoconjunctivitis sicca and arthritis. Splenomegaly occurred in 14 (28 per cent) patients. The percentage of B lymphocytes in the blood was determined in 10 patients; it was normal or slightly decreased in eight patients and low in two patients.
Similar articles
- Immunodeficiency syndromes and gastrointestinal disease.
Ament ME. Ament ME. Pediatr Clin North Am. 1975 Nov;22(4):807-25. doi: 10.1016/s0031-3955(16)33209-6. Pediatr Clin North Am. 1975. PMID: 1105363 Review. No abstract available. - [Diarrhea and primary immunoglobulin deficiency in adults].
Huet PM, Modigliani R, Bognel JC, Rambaud JC, Hirsch-Marie H, Rautureau M, Hartmann L, Bernier JJ. Huet PM, et al. Pathol Biol (Paris). 1972 Sep;20(15):661-80. Pathol Biol (Paris). 1972. PMID: 4562040 French. No abstract available. - [Clinical studies of pediatric malabsorption syndromes].
Hosoyamada T. Hosoyamada T. Fukuoka Igaku Zasshi. 2006 Nov;97(11):322-50. Fukuoka Igaku Zasshi. 2006. PMID: 17228786 Japanese. - Nodular lymphoid hyperplasia of the small intestine and colon with giardiasis. A case with borderline serum IgA levels.
Milano AM, Lawrence LR, Horowitz L. Milano AM, et al. Am J Dig Dis. 1971 Aug;16(8):735-7. doi: 10.1007/BF02239601. Am J Dig Dis. 1971. PMID: 5096789 No abstract available. - Current perspectives on giardiasis.
Fisher CH, Oh KS, Bayless TM, Siegelman SS. Fisher CH, et al. Am J Roentgenol Radium Ther Nucl Med. 1975 Sep;125(1):207-17. doi: 10.2214/ajr.125.1.207. Am J Roentgenol Radium Ther Nucl Med. 1975. PMID: 1106221 Review.
Cited by
- Expression of Toll-like Receptors on the Immune Cells in Patients with Common Variable Immune Deficiency after Different Schemes of Influenza Vaccination.
Kostinova AM, Latysheva EA, Akhmatova NK, Vlasenko AE, Skhodova SA, Khromova EA, Linok AV, Poddubikov AA, Latysheva TV, Kostinov MP. Kostinova AM, et al. Viruses. 2023 Oct 14;15(10):2091. doi: 10.3390/v15102091. Viruses. 2023. PMID: 37896869 Free PMC article. - Immunogenetics of gastrointestinal cancers: A systematic review and retrospective survey of inborn errors of immunity in humans.
Zheng B, Artin MG, Chung H, Chen B, Sun S, May BL, Hur C, Green PHR, Wang TC, Park J, Kong XF. Zheng B, et al. J Gastroenterol Hepatol. 2022 Jun;37(6):973-982. doi: 10.1111/jgh.15848. Epub 2022 Apr 13. J Gastroenterol Hepatol. 2022. PMID: 35384041 Free PMC article. Review. - Small and Large Intestine (I): Malabsorption of Nutrients.
Montoro-Huguet MA, Belloc B, Domínguez-Cajal M. Montoro-Huguet MA, et al. Nutrients. 2021 Apr 11;13(4):1254. doi: 10.3390/nu13041254. Nutrients. 2021. PMID: 33920345 Free PMC article. Review. - Gastrointestinal Disease in Patients with Common Variable Immunodeficiency: A Retrospective Observational Study.
Khan R, Habbal M, Scaffidi MA, Bukhari AA, Rumman A, Al Ghamdi S, Betschel SD, Grover SC. Khan R, et al. J Can Assoc Gastroenterol. 2020 Aug;3(4):162-168. doi: 10.1093/jcag/gwz004. Epub 2019 Feb 25. J Can Assoc Gastroenterol. 2020. PMID: 32671325 Free PMC article. - Immunoglobulin profile and B-cell frequencies are altered with changes in the cellular microenvironment independent of the stimulation conditions.
Moore DK, Leisching GR, Snyders CI, Gutschmidt A, van Rensburg IC, Loxton AG. Moore DK, et al. Immun Inflamm Dis. 2020 Sep;8(3):458-467. doi: 10.1002/iid3.328. Epub 2020 Jul 8. Immun Inflamm Dis. 2020. PMID: 32639690 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases