Transcription factor ATF2 regulation by the JNK signal transduction pathway - PubMed (original) (raw)

. 1995 Jan 20;267(5196):389-93.

doi: 10.1126/science.7824938.

Affiliations

• PMID: 7824938
• DOI: 10.1126/science.7824938

Transcription factor ATF2 regulation by the JNK signal transduction pathway

S Gupta et al. Science. 1995.

Abstract

Treatment of cells with pro-inflammatory cytokines or ultraviolet radiation causes activation of the c-Jun NH2-terminal protein kinase (JNK). Activating transcription factor-2 (ATF2) was found to be a target of the JNK signal transduction pathway. ATF2 was phosphorylated by JNK on two closely spaced threonine residues within the NH2-terminal activation domain. The replacement of these phosphorylation sites with alanine inhibited the transcriptional activity of ATF2. These mutations also inhibited ATF2-stimulated gene expression mediated by the retinoblastoma (Rb) tumor suppressor and the adenovirus early region 1A (E1A) oncoprotein. Furthermore, expression of dominant-negative JNK inhibited ATF2 transcriptional activity. Together, these data demonstrate a role for the JNK signal transduction pathway in transcriptional responses mediated by ATF2.

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