Tumor-suppressor gene products in cell contacts: the cadherin-APC-armadillo connection - PubMed (original) (raw)

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Tumor-suppressor gene products in cell contacts: the cadherin-APC-armadillo connection

J Hülsken et al. Curr Opin Cell Biol. 1994 Oct.

Abstract

Various structural components of intercellular junctions have recently been found to represent (or be related to) products of tumor-suppressor genes. The tumor-suppressor gene product adenomatous polyposis coli (APC) binds to beta 2-catenin (homologous to the product of Drosophila armadillo), which is cytoplasmically associated with the cell adhesion molecule E-cadherin.

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