Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel family - PubMed (original) (raw)
Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel family
F Weih et al. Cell. 1995.
Free article
Abstract
RelB, a member of the NF-kappa B/Rel family of transcription factors, has been implicated in the constitutive expression of kappa B-regulated genes in lymphoid tissues. We have generated mice carrying a germline mutation of the relB gene, resulting in the absence of RelB protein and a dramatic reduction of constitutive kappa B-binding activity in thymus and spleen. Mice homozygous for the disrupted relB locus had phenotypic abnormalities including multifocal, mixed inflammatory cell infiltration in several organs, myeloid hyperplasia, splenomegaly due to extramedullary hematopoiesis, and a reduced population of thymic dendritic cells. RelB-deficient animals also had an impaired cellular immunity, as observed in contact sensitivity experiments. Thus, RelB plays a decisive role in the hematopoietic system, and its absence cannot be functionally compensated by any other member of the NF-kappa B/Rel family.
Similar articles
- RelB, a member of the Rel/NF-kappa B family of transcription factors.
Ryseck RP, Weih F, Carrasco D, Bravo R. Ryseck RP, et al. Braz J Med Biol Res. 1996 Jul;29(7):895-903. Braz J Med Biol Res. 1996. PMID: 9070378 Review. - p50-NF-kappaB complexes partially compensate for the absence of RelB: severely increased pathology in p50(-/-)relB(-/-) double-knockout mice.
Weih F, Durham SK, Barton DS, Sha WC, Baltimore D, Bravo R. Weih F, et al. J Exp Med. 1997 Apr 7;185(7):1359-70. doi: 10.1084/jem.185.7.1359. J Exp Med. 1997. PMID: 9104822 Free PMC article. - Both multiorgan inflammation and myeloid hyperplasia in RelB-deficient mice are T cell dependent.
Weih F, Durham SK, Barton DS, Sha WC, Baltimore D, Bravo R. Weih F, et al. J Immunol. 1996 Nov 1;157(9):3974-9. J Immunol. 1996. PMID: 8892630 - Constitutive and inducible Rel/NF-kappa B activities in mouse thymus and spleen.
Weih F, Carrasco D, Bravo R. Weih F, et al. Oncogene. 1994 Nov;9(11):3289-97. Oncogene. 1994. PMID: 7936653 - Genetic approaches to study Rel/NF-kappa B/I kappa B function in mice.
Attar RM, Caamaño J, Carrasco D, Iotsova V, Ishikawa H, Ryseck RP, Weih F, Bravo R. Attar RM, et al. Semin Cancer Biol. 1997 Apr;8(2):93-101. doi: 10.1006/scbi.1997.0060. Semin Cancer Biol. 1997. PMID: 9299587 Review.
Cited by
- NF-κB-Mediated Regulation of Osteoclastogenesis.
Boyce BF, Xiu Y, Li J, Xing L, Yao Z. Boyce BF, et al. Endocrinol Metab (Seoul). 2015 Mar 27;30(1):35-44. doi: 10.3803/EnM.2015.30.1.35. Endocrinol Metab (Seoul). 2015. PMID: 25827455 Free PMC article. Review. - RelB contributes to the survival, migration and lymphomagenesis of B cells with constitutively active CD40 signaling.
Kuhn LB, Valentin S, Stojanovic K, Strobl DC, Babushku T, Wang Y, Rambold U, Scheffler L, Grath S, John-Robbert D, Blum H, Feuchtinger A, Blutke A, Weih F, Kitamura D, Rad R, Strobl LJ, Zimber-Strobl U. Kuhn LB, et al. Front Immunol. 2022 Aug 30;13:913275. doi: 10.3389/fimmu.2022.913275. eCollection 2022. Front Immunol. 2022. PMID: 36110848 Free PMC article. - MicroRNA-375 regulation of thymic stromal lymphopoietin by diesel exhaust particles and ambient particulate matter in human bronchial epithelial cells.
Bleck B, Grunig G, Chiu A, Liu M, Gordon T, Kazeros A, Reibman J. Bleck B, et al. J Immunol. 2013 Apr 1;190(7):3757-63. doi: 10.4049/jimmunol.1201165. Epub 2013 Mar 1. J Immunol. 2013. PMID: 23455502 Free PMC article. - RelB nuclear translocation regulates B cell MHC molecule, CD40 expression, and antigen-presenting cell function.
O'Sullivan BJ, MacDonald KP, Pettit AR, Thomas R. O'Sullivan BJ, et al. Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11421-6. doi: 10.1073/pnas.97.21.11421. Proc Natl Acad Sci U S A. 2000. PMID: 11027342 Free PMC article. - RelB upregulates PD-L1 and exacerbates prostate cancer immune evasion.
Zhang Y, Zhu S, Du Y, Xu F, Sun W, Xu Z, Wang X, Qian P, Zhang Q, Feng J, Xu Y. Zhang Y, et al. J Exp Clin Cancer Res. 2022 Feb 17;41(1):66. doi: 10.1186/s13046-022-02243-2. J Exp Clin Cancer Res. 2022. PMID: 35177112 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases
Research Materials