CTLA4 mediates antigen-specific apoptosis of human T cells - PubMed (original) (raw)
CTLA4 mediates antigen-specific apoptosis of human T cells
J G Gribben et al. Proc Natl Acad Sci U S A. 1995.
Abstract
The regulation of T cell-mediated immune responses requires a balance between amplification and generation of effector function and subsequent selective termination by clonal deletion. Although apoptosis of previously activated T cells can be induced by signaling of the tumor necrosis factor receptor family, these molecules do not appear to regulate T-cell clonal deletion in an antigen-specific fashion. We demonstrate that cross-linking of the inducible T-cell surface molecule CTLA4 can mediate apoptosis of previously activated human T lymphocytes. This function appears to be antigen-restricted, since a concomitant signal T-cell receptor signal is required. Regulation of this pathway may provide a novel therapeutic strategy to delete antigen-specific activated T cells.
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References
- J Exp Med. 1989 May 1;169(5):1747-56 - PubMed
- J Exp Med. 1991 Sep 1;174(3):561-9 - PubMed
- Cell. 1990 Dec 21;63(6):1249-56 - PubMed
- J Exp Med. 1991 Mar 1;173(3):721-30 - PubMed
- Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2151-5 - PubMed
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