Genomic imprinting--defusing the ovarian time bomb - PubMed (original) (raw)
Genomic imprinting--defusing the ovarian time bomb
S Varmuza et al. Trends Genet. 1994 Apr.
Abstract
Why do mammals imprint their parental genomes? Imprinting is seen in many phyla, but that in mammals is by far the most dramatic. Is there something peculiar to mammals that calls for such a striking phenomenon? We propose that imprinting is a device that protects female mammals from the potential ravages of ovarian trophoblast disease. Without imprinting, the ovarian teratomas that frequently arise from parthenogenetically activated oocytes in situ might be capable of forming malignant trophoblast. An allele that favored imprinting would spread rapidly because of the great increase in fitness associated with suppressing a lethal cancer of females.
Comment in
- Refusing the ovarian time bomb.
Moore T. Moore T. Trends Genet. 1994 Oct;10(10):347-9. doi: 10.1016/0168-9525(94)90122-8. Trends Genet. 1994. PMID: 7848486 No abstract available. - Refusing the ovarian time bomb.
Solter D. Solter D. Trends Genet. 1994 Oct;10(10):346; author reply 348-9. doi: 10.1016/0168-9525(94)90120-1. Trends Genet. 1994. PMID: 7985237 No abstract available. - Refusing the ovarian time bomb.
Haig D. Haig D. Trends Genet. 1994 Oct;10(10):346-7; author reply 348-9. doi: 10.1016/0168-9525(94)90121-x. Trends Genet. 1994. PMID: 7985238 No abstract available.
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