Origin and molecular epidemiology of penicillin-binding-protein-mediated resistance to beta-lactam antibiotics - PubMed (original) (raw)
Origin and molecular epidemiology of penicillin-binding-protein-mediated resistance to beta-lactam antibiotics
C G Dowson et al. Trends Microbiol. 1994 Oct.
Abstract
Resistance to beta-lactam antibiotics in some naturally transformable bacterial pathogens has arisen by interspecies recombinational events that have generated hybrid penicillin-binding proteins with reduced affinity for the antibiotics. This type of resistance is of particular concern in pneumococci, in which it is increasing worldwide.