Serum levels of laminin, type IV collagen and type III procollagen peptide as markers for detection of metastasis - PubMed (original) (raw)
Serum levels of laminin, type IV collagen and type III procollagen peptide as markers for detection of metastasis
K Yudoh et al. Jpn J Cancer Res. 1994 Dec.
Abstract
We investigated the clinical usefulness of serum laminin, type IV collagen and type III procollagen peptide (PIIIP) as markers for detection of metastasis in patients with primary or metastatic bone and soft part tumors. The subjects consisted of 28 patients with metastatic bone tumors, 18 with primary bone tumors (benign; 10, malignant; 8), 22 with primary soft part tumors (benign; 12, malignant; 10), 18 with cancer without metastasis (as controls to metastatic bone tumor) and 60 healthy controls. Elevated levels of serum laminin, type IV collagen and PIIIP were not associated with any specific histological subtype, tumor size or location, and were clearly related to evidence of metastasis. Mean serum concentrations of laminin, type IV collagen and PIIIP were significantly higher in patients with metastasis than in patients without metastasis. Positive correlations were observed among serum laminin, type IV collagen and PIIIP levels in tumor patients. The sensitivity values for laminin, type IV collagen and PIIIP in detecting metastasis were 83.7%, 83.3% and 80.5%, respectively, with specificity of 90.0%, 86.1% and 86.1%. When two of the three markers were evaluated in identical blood samples, combined sensitivity and specificity values exhibited further increases as compared to the sensitivity and specificity of each marker. The use of all three markers led to the best combined sensitivity and specificity. These findings suggest that the combination of these markers would be a valuable screening test in predicting metastasis.
Similar articles
- Serum carboxy-terminal cross-linked telopeptide of type I collagen reflects bone metastasis in hepatocellular carcinoma.
Ueno T, Hashimoto O, Sugawara H, Ogata R, Kusaba N, Torimura T, Sata M, Tanikawa K. Ueno T, et al. Int J Oncol. 1998 Aug;13(2):297-303. doi: 10.3892/ijo.13.2.297. Int J Oncol. 1998. PMID: 9664125 - Serum markers for hepatic fibrosis in alcoholic liver disease: which is the best marker, type III procollagen, type IV collagen, laminin, tissue inhibitor of metalloproteinase, or prolyl hydroxylase?
Tsutsumi M, Takase S, Urashima S, Ueshima Y, Kawahara H, Takada A. Tsutsumi M, et al. Alcohol Clin Exp Res. 1996 Dec;20(9):1512-7. doi: 10.1111/j.1530-0277.1996.tb01692.x. Alcohol Clin Exp Res. 1996. PMID: 8986196 - Prognostic value of serum procollagen III peptide and type IV collagen in patients with biliary atresia.
Kobayashi H, Miyano T, Horikoshi K, Tokita A. Kobayashi H, et al. J Pediatr Surg. 1998 Jan;33(1):112-4. doi: 10.1016/s0022-3468(98)90374-8. J Pediatr Surg. 1998. PMID: 9473113 - Serum type IV collagen in various liver diseases in comparison with serum 7S collagen, laminin, and type III procollagen peptide.
Hirayama C, Suzuki H, Takada A, Fujisawa K, Tanikawa K, Igarashi S. Hirayama C, et al. J Gastroenterol. 1996 Apr;31(2):242-8. doi: 10.1007/BF02389524. J Gastroenterol. 1996. PMID: 8680545
Cited by
- Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrin.
Hamano Y, Zeisberg M, Sugimoto H, Lively JC, Maeshima Y, Yang C, Hynes RO, Werb Z, Sudhakar A, Kalluri R. Hamano Y, et al. Cancer Cell. 2003 Jun;3(6):589-601. doi: 10.1016/s1535-6108(03)00133-8. Cancer Cell. 2003. PMID: 12842087 Free PMC article. - Nitric oxide induced by tumor cells activates tumor cell adhesion to endothelial cells and permeability of the endothelium in vitro.
Yudoh K, Matsui H, Tsuji H. Yudoh K, et al. Clin Exp Metastasis. 1997 Nov;15(6):557-67. doi: 10.1023/a:1018487213157. Clin Exp Metastasis. 1997. PMID: 9344040 - Tumor cell attachment to laminin promotes degradation of the extracellular matrix and cell migration in high-metastatic clone cells of RCT sarcoma in vitro.
Yudoh K, Matsui H, Kanamori M, Ohmori K, Tsuji H. Yudoh K, et al. Jpn J Cancer Res. 1995 Jul;86(7):685-90. doi: 10.1111/j.1349-7006.1995.tb02453.x. Jpn J Cancer Res. 1995. PMID: 7559087 Free PMC article.
References
- ) Schajowicz , F. and Mcguire , M. H.Diagnostic difficulties in skeletal pathology . Clin. Orthop. , 240 , 281 – 310 ( 1989. ). - PubMed
- ) Khurana , J. S. , Rosenthal , D. I. , Rosenberg , A. E. and Mankin , H. J.Skeletal metastases in liposarcoma detectable only by magnetic resonance imaging . Clin. Orthop. , 243 , 204 – 207 ( 1989. ). - PubMed
- ) Liotta , L. A. , Rao , C. N. and Wewer , U. N.Biochemical interactions of tumor cells with the basement membrane . Annu. Rev. Biochem. , 55 , 1037 – 1057 ( 1986. ). - PubMed
- ) Liotta , L. A.Tumor invasion and metastases – role of the extracellular matrix: Rhoades Memorial Award Lecture . Cancer Res. , 46 , 1 – 7 ( 1986. ). - PubMed
- ) Volk , T. , Geiger , B. and Raz , A.Motility and adhesive properties of high‐ and low‐metastatic neoplastic cells . Cancer Res. , 44 , 811 – 824 ( 1984. ). - PubMed
MeSH terms
Substances
LinkOut - more resources
Full Text Sources