Differential inhibition by iodonium compounds of induced erythropoietin expression - PubMed (original) (raw)
. 1995 Feb 10;270(6):2628-9.
doi: 10.1074/jbc.270.6.2628.
Affiliations
- PMID: 7852328
- DOI: 10.1074/jbc.270.6.2628
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Differential inhibition by iodonium compounds of induced erythropoietin expression
E Goldwasser et al. J Biol Chem. 1995.
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Abstract
Diphenylene iodonium chloride suppresses the cobaltous chloride-induced expression of erythropoietin by Hep3B cells to about 50% at a concentration of 30 nM. At that concentration, it has no effect on the response to low oxygen. The related compound iodonium diphenyl chloride acts similarly but is a much less effective inhibitor. If, as reported, diphenylene iodonium chloride is a specific inhibitor of cytochrome b, it follows that the response to CoCl2 is dependent on that enzyme but the response to hypoxia is not.
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