Increase of extracellular dopamine in the prefrontal cortex: a trait of drugs with antidepressant potential? - PubMed (original) (raw)

. 1994 Jun;115(1-2):285-8.

doi: 10.1007/BF02244785.

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Increase of extracellular dopamine in the prefrontal cortex: a trait of drugs with antidepressant potential?

G Tanda et al. Psychopharmacology (Berl). 1994 Jun.

Abstract

Drugs differing in their primary mechanism of action but having in common the ability to act as antidepressants such as fluoxetine (10 mg/kg SC), clomipramine (10 mg/kg IP), imipramine (10 mg/kg IP), desipramine (10 mg/kg IP) and (+/-) 8-OHDPAT (0.03 mg/kg SC) increase extracellular concentrations of dopamine in the rat prefrontal cortex but not in the medial nucleus accumbens. Buspirone (1 mg/kg SC) increased dopamine both in the prefrontal cortex and in the nucleus accumbens. Extracellular 5HT was increased by fluoxetine, clomipramine and imipramine but not by desipramine while 8-OHDPAT and buspirone decreased it. These results raise the possibility that the property of stimulating dopamine transmission in the prefrontal cortex has a role in the antidepressant properties of these drugs.

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