The insulin-like growth factor-I receptor. Structure, ligand-binding mechanism and signal transduction - PubMed (original) (raw)
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The insulin-like growth factor-I receptor. Structure, ligand-binding mechanism and signal transduction
P De Meyts et al. Horm Res. 1994.
Abstract
The nonclassical binding kinetics of IGF-I and insulin to their respective receptors, suggestive of negative cooperativity, can be readily explained by our recently proposed novel binding mechanism whereby the bivalent ligand bridges the two receptor alpha-subunits alternatively at opposite sites in a symmetrical receptor structure. The bivalent binding mechanism also explains bell-shaped bioactivity curves. The possible role of different binding modes versus differences in downstream signaling by insulin and IGF-I in producing specific mitogenic or metabolic responses is discussed.
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