An HMG-box-containing T-cell factor required for thymocyte differentiation - PubMed (original) (raw)

. 1995 Mar 2;374(6517):70-4.

doi: 10.1038/374070a0.

Affiliations

• PMID: 7870176
• DOI: 10.1038/374070a0

An HMG-box-containing T-cell factor required for thymocyte differentiation

S Verbeek et al. Nature. 1995.

Abstract

Two candidate genes for controlling thymocyte differentiation, T-cell factor-1 (Tcf-1) and lymphoid enhancer-binding factor (Lef-1), encode closely related DNA-binding HMG-box proteins. Their expression pattern is complex and largely overlapping during embryogenesis, yet restricted to lymphocytes postnatally. Here we generate two independent germline mutations in Tcf-1 and find that thymocyte development in (otherwise normal) mutant mice is blocked at the transition from the CD8+, immature single-positive to the CD4+/CD8+ double-positive stage. In contrast to wild-type mice, most of the immature single-positive cells in the mutants are not in the cell cycle and the number of immunocompetent T cells in peripheral lymphoid organs is reduced. We conclude that Tcf-1 controls an essential step in thymocyte differentiation.

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