Events per person year--a dubious concept - PubMed (original) (raw)
Events per person year--a dubious concept
J Windeler et al. BMJ. 1995.
Abstract
In 1982 a new measure was introduced in research into osteoporosis and is now used everywhere in the literature. The so called "fracture rate" relates the number of fractures (single in some patients, multiple in others) to the cumulative time of observation of all patients. This concept, however, has no sound basis. Counting events instead of patients usually violates basic statistical assumptions and invalidates the use of common statistical tests and estimators. Its clinical interpretation is rather dubious. The use of such a measure impedes the search for valid and clinically meaningful outcome criteria and should be abandoned.
Comment in
- Events per person year. A decrease in multiple events may be missed.
Kanis JA, McCloskey EV. Kanis JA, et al. BMJ. 1995 Jun 3;310(6992):1469. doi: 10.1136/bmj.310.6992.1469a. BMJ. 1995. PMID: 7613296 Free PMC article. No abstract available. - Events per person year. Use individual event rate adjustment for follow up time.
Löyttyniemi E, Laitinen K, Tuominen J. Löyttyniemi E, et al. BMJ. 1995 Jun 3;310(6992):1469-70. doi: 10.1136/bmj.310.6992.1469b. BMJ. 1995. PMID: 7646729 Free PMC article. No abstract available. - Events per person year. Can obscure the true risk of certain adverse drug reactions.
Paterson KR. Paterson KR. BMJ. 1995 Jun 3;310(6992):1470. doi: 10.1136/bmj.310.6992.1470. BMJ. 1995. PMID: 7677865 Free PMC article. No abstract available.
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