Early high-affinity neutralizing anti-viral IgG responses without further overall improvements of affinity - PubMed (original) (raw)
Early high-affinity neutralizing anti-viral IgG responses without further overall improvements of affinity
H P Roost et al. Proc Natl Acad Sci U S A. 1995.
Abstract
Affinity maturation of IgG antibodies in adaptive immune responses is a well-accepted mechanism to improve effector functions of IgG within 2 weeks to several months of antigen encounter. This concept has been defined mainly for IgG responses against chemically defined haptens. We have evaluated this concept in a viral system and analyzed neutralizing IgG antibody responses against vesicular stomatitis virus (a close relative of rabies virus) with a panel of monoclonal antibodies obtained early (day 6 or 12) and late (day 150) after hyperimmunization. These neutralizing IgG antibodies recognize a single major antigenic site with high affinities (Ka of 10(8)-10(10) liter.mol-1) and with rapid on-rates already on day 6 of a primary response and with no evidence for further antigen dose- and time-dependent overall improvement of affinity. This type of IgG response is probably representative for viruses or bacterial toxins which are crucially controlled by neutralizing antibodies.
Comment in
- Kinetic and affinity limits on antibodies produced during immune responses.
Foote J, Eisen HN. Foote J, et al. Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1254-6. doi: 10.1073/pnas.92.5.1254. Proc Natl Acad Sci U S A. 1995. PMID: 7877964 Free PMC article. No abstract available.
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