Development of a mouse model of Helicobacter pylori infection that mimics human disease - PubMed (original) (raw)

. 1995 Mar 17;267(5204):1655-8.

doi: 10.1126/science.7886456.

Affiliations

• PMID: 7886456
• DOI: 10.1126/science.7886456

Development of a mouse model of Helicobacter pylori infection that mimics human disease

M Marchetti et al. Science. 1995.

Abstract

The human pathogen Helicobacter pylori is associated with gastritis, peptic ulcer disease, and gastric cancer. The pathogenesis of H. pylori infection in vivo was studied by adapting fresh clinical isolates of bacteria to colonize the stomachs of mice. A gastric pathology resembling human disease was observed in infections with cytotoxin-producing strains but not with noncytotoxic strains. Oral immunization with purified H. pylori antigens protected mice from bacterial infection. This mouse model will allow the development of therapeutic agents and vaccines against H. pylori infection in humans.

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Comment in

• The new path to preventing ulcers.
  Tompkins LS, Falkow S. Tompkins LS, et al. Science. 1995 Mar 17;267(5204):1621-2. doi: 10.1126/science.7886448. Science. 1995. PMID: 7886448 Review. No abstract available.

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