An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3 - PubMed (original) (raw)

An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3

N Schreiber-Agus et al. Cell. 1995.

Free article

Abstract

Documented interactions among members of the Myc superfamily support a yin-yang model for the regulation of Myc-responsive genes in which transactivation-competent Myc-Max heterodimers are opposed by repressive Mxi1-Max or Mad-Max complexes. Analysis of mouse mxi1 has led to the identification of two mxi1 transcript forms possessing open reading frames that differ in their capacity to encode a short amino-terminal alpha-helical domain. The presence of this segment dramatically augments the suppressive potential of Mxi1 and allows for association with a mammalian protein that is structurally homologous to the yeast transcriptional repressor SIN3. These findings provide a mechanistic basis for the antagonistic actions of Mxi1 on Myc activity that appears to be mediated in part through the recruitment of a putative transcriptional repressor.

PubMed Disclaimer

Similar articles

• Mouse Sin3A interacts with and can functionally substitute for the amino-terminal repression of the Myc antagonist Mxi1.
  Rao G, Alland L, Guida P, Schreiber-Agus N, Chen K, Chin L, Rochelle JM, Seldin MF, Skoultchi AI, DePinho RA. Rao G, et al. Oncogene. 1996 Mar 7;12(5):1165-72. Oncogene. 1996. PMID: 8649810
• Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3.
  Ayer DE, Lawrence QA, Eisenman RN. Ayer DE, et al. Cell. 1995 Mar 10;80(5):767-76. doi: 10.1016/0092-8674(95)90355-0. Cell. 1995. PMID: 7889570
• Sin3 corepressor function in Myc-induced transcription and transformation.
  Harper SE, Qiu Y, Sharp PA. Harper SE, et al. Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8536-40. doi: 10.1073/pnas.93.16.8536. Proc Natl Acad Sci U S A. 1996. PMID: 8710905 Free PMC article.
• Repression by the Mad(Mxi1)-Sin3 complex.
  Schreiber-Agus N, DePinho RA. Schreiber-Agus N, et al. Bioessays. 1998 Oct;20(10):808-18. doi: 10.1002/(SICI)1521-1878(199810)20:10<808::AID-BIES6>3.0.CO;2-U. Bioessays. 1998. PMID: 9819568 Review.
• Transcriptional regulation. Flipping the Myc switch.
  Bernards R. Bernards R. Curr Biol. 1995 Aug 1;5(8):859-61. doi: 10.1016/s0960-9822(95)00173-4. Curr Biol. 1995. PMID: 7583141 Review.

Cited by

• Transcription regulation strategies in methylotrophs: progress and challenges.
  Huang X, Song Q, Guo S, Fei Q. Huang X, et al. Bioresour Bioprocess. 2022 Dec 12;9(1):126. doi: 10.1186/s40643-022-00614-3. Bioresour Bioprocess. 2022. PMID: 38647763 Free PMC article. Review.
• Sumoylation of SAP130 regulates its interaction with FAF1 as well as its protein stability and transcriptional repressor function.
  Chen CH, Lin HW, Huang MF, Chiang CW, Lee KH, Phuong NT, Cai ZY, Chang WC, Lin DY. Chen CH, et al. BMC Mol Cell Biol. 2024 Jan 4;25(1):2. doi: 10.1186/s12860-023-00498-x. BMC Mol Cell Biol. 2024. PMID: 38172660 Free PMC article.
• Chromatin-Associated SIN3B Protects Cancer Cells from Genotoxic Stress-Induced Apoptosis and Dictates DNA Damage Repair Pathway Choice.
  Morales-Valencia J, Petit C, Calderon A, Saini S, David G. Morales-Valencia J, et al. Mol Cancer Res. 2023 Sep 1;21(9):947-957. doi: 10.1158/1541-7786.MCR-22-0466. Mol Cancer Res. 2023. PMID: 37314748 Free PMC article.
• Reprogramming by drug-like molecules leads to regeneration of cochlear hair cell-like cells in adult mice.
  Quan YZ, Wei W, Ergin V, Rameshbabu AP, Huang M, Tian C, Saladi SV, Indzhykulian AA, Chen ZY. Quan YZ, et al. Proc Natl Acad Sci U S A. 2023 Apr 25;120(17):e2215253120. doi: 10.1073/pnas.2215253120. Epub 2023 Apr 17. Proc Natl Acad Sci U S A. 2023. PMID: 37068229 Free PMC article.
• The effects of MYC on tumor immunity and immunotherapy.
  Li J, Dong T, Wu Z, Zhu D, Gu H. Li J, et al. Cell Death Discov. 2023 Mar 25;9(1):103. doi: 10.1038/s41420-023-01403-3. Cell Death Discov. 2023. PMID: 36966168 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations

• Molecular Biology Databases

  • BioCyc
  • GlyGen glycoinformatics resource
  • Mouse Genome Informatics (MGI)
  • Saccharomyces Genome Database