Olive oil decreases liver damage in rats caused by carbon tetrachloride (CCl4) - PubMed (original) (raw)
Olive oil decreases liver damage in rats caused by carbon tetrachloride (CCl4)
B Szende et al. Exp Toxicol Pathol. 1994 Oct.
Abstract
Oral carbon tetrachloride (CCl4) poisoning of the liver of male F-344 rats was modified by dissolving CCl4 in various oils (sunflower, corn, fish and olive). After 8 weeks of CCl4 treatment (3 x 0.2 ml/kg body weight every other day, dissolved in aliquots of 0.5 ml of each types of oil) the rats were sacrificed and the ratio of connective tissue in the liver was determined by morphometry after picrosirius staining. The percentage of collagen fibres increased in all CCl4-treated groups compared to the controls. This increase was almost the same (6-8%) in the case of CCl4 dissolved in sunflower, corn or fish oil, but when olive oil was applied as a solvent, the collagen ratio was only 2-4 percent. On the bases of this finding olive oil is considered as less harmful to the liver in acute CCl4 poisoning than other oils.
Similar articles
- Differential protective effects of extra virgin olive oil and corn oil in liver injury: a proteomic study.
Wang H, Sit WH, Tipoe GL, Wan JM. Wang H, et al. Food Chem Toxicol. 2014 Dec;74:131-8. doi: 10.1016/j.fct.2014.09.002. Epub 2014 Oct 7. Food Chem Toxicol. 2014. PMID: 25303780 - Effect of oral dosing vehicles on the subchronic hepatotoxicity of carbon tetrachloride in the rat.
Koporec KP, Kim HJ, MacKenzie WF, Bruckner JV. Koporec KP, et al. J Toxicol Environ Health. 1995 Jan;44(1):13-27. doi: 10.1080/15287399509531940. J Toxicol Environ Health. 1995. PMID: 7823328 - Acetone potentiation of chronic liver injury induced by repetitive administration of carbon tetrachloride.
Charbonneau M, Tuchweber B, Plaa GL. Charbonneau M, et al. Hepatology. 1986 Jul-Aug;6(4):694-700. doi: 10.1002/hep.1840060426. Hepatology. 1986. PMID: 3733003 - Cardiovascular effects of edible oils: a comparison between four popular edible oils.
Bester D, Esterhuyse AJ, Truter EJ, van Rooyen J. Bester D, et al. Nutr Res Rev. 2010 Dec;23(2):334-48. doi: 10.1017/S0954422410000223. Epub 2010 Sep 20. Nutr Res Rev. 2010. PMID: 20849681 Review. - [The effect of D-penicillamine on experimental liver cirrhosis induced by CCl4].
Schaff Z, Lapis K, Szende B, Jeney A, Gonzales Cabello R, Gergely P, Simon K, Divald A, Timár F, Major J. Schaff Z, et al. Morphol Igazsagugyi Orv Sz. 1990 Jul;30(3):161-9. Morphol Igazsagugyi Orv Sz. 1990. PMID: 2233769 Review. Hungarian.
Cited by
- Potential Hepatoprotective Activity of Super Critical Carbon Dioxide Olive Leaf Extracts against CCl4-Induced Liver Damage.
Taamalli A, Feriani A, Lozano-Sanchez J, Ghazouani L, El Mufti A, Allagui MS, Segura-Carretero A, Mhamdi R, Arráez-Roman D. Taamalli A, et al. Foods. 2020 Jun 18;9(6):804. doi: 10.3390/foods9060804. Foods. 2020. PMID: 32570798 Free PMC article. - Evaluation of Pistacia lentiscus fatty oil effects on glycemic index, liver functions and kidney functions of New Zealand rabbits.
Djerrou Z, Hamdi-Pacha Y, Belkhiri AM, Djaalab H, Riachi F, Serakta M, Boukeloua A, Maameri Z. Djerrou Z, et al. Afr J Tradit Complement Altern Med. 2011;8(5 Suppl):214-9. doi: 10.4314/ajtcam.v8i5S.27. Epub 2011 Jul 3. Afr J Tradit Complement Altern Med. 2011. PMID: 22754077 Free PMC article. - Pharmacological Evaluation of Scopoletin in the Carbon Tetrachloride-Induced Hepatotoxicity Model in Wistar Rats.
Sharma S, Anand A, Bhatia A, Sharma V, Singh AK, Banerjee D, Patil AN. Sharma S, et al. J Pharm Bioallied Sci. 2022 Oct-Dec;14(4):201-206. doi: 10.4103/jpbs.jpbs_333_22. Epub 2023 Feb 17. J Pharm Bioallied Sci. 2022. PMID: 37051421 Free PMC article. - Suaeda vermiculata Aqueous-Ethanolic Extract-Based Mitigation of CCl4-Induced Hepatotoxicity in Rats, and HepG-2 and HepG-2/ADR Cell-Lines-Based Cytotoxicity Evaluations.
Mohammed SAA, Khan RA, El-Readi MZ, Emwas AH, Sioud S, Poulson BG, Jaremko M, Eldeeb HM, Al-Omar MS, Mohammed HA. Mohammed SAA, et al. Plants (Basel). 2020 Sep 29;9(10):1291. doi: 10.3390/plants9101291. Plants (Basel). 2020. PMID: 33003604 Free PMC article. - Steatosis recovery after treatment with a balanced sunflower or olive oil-based diet: involvement of perisinusoidal stellate cells.
Hernández R, Martínez-Lara E, Cañuelo A, del Moral ML, Blanco S, Siles E, Jiménez A, Pedrosa JA, Peinado MA. Hernández R, et al. World J Gastroenterol. 2005 Dec 21;11(47):7480-5. doi: 10.3748/wjg.v11.i47.7480. World J Gastroenterol. 2005. PMID: 16437720 Free PMC article.