The pattern of attentional deficits in Huntington's disease - PubMed (original) (raw)
. 1995 Feb:118 ( Pt 1):145-52.
doi: 10.1093/brain/118.1.145.
Affiliations
- PMID: 7895000
- DOI: 10.1093/brain/118.1.145
The pattern of attentional deficits in Huntington's disease
R Sprengelmeyer et al. Brain. 1995 Feb.
Abstract
Different aspects of attention, e.g. phasic alertness, vigilance, divided attention, response flexibility, response inhibition and intermodal integration, were investigated with a computerized test-battery in a group of 20 patients with Huntington's disease and 27 healthy controls. Huntington's disease patients are not impaired in reacting to task-contingent external stimulation in the phasic alertness task, but the self-generated maintenance of attention as measured by the vigilance task, is disturbed. The simultaneous monitoring of different input-channels in the divided attention task and the ability to operate with information given to different modalities in the intermodal integration task are severely affected. The performance of Huntington's disease patients in the response flexibility task, in which internal cued shifts are required, is impaired. Huntington's disease patients are also impaired in reacting selectively to go/no-go stimuli in the response inhibition task. It is suggested that a number of 'higher' cognitive deficits described in Huntington's disease might, at least partly, be due to basic attentional disturbances.
Similar articles
- Disturbance of "extrinsic alertness" in Huntington's disease.
Müller SV, Jung A, Preinfalk J, Kolbe H, Ridao-Alonso M, Dengler R, Münte TF. Müller SV, et al. J Clin Exp Neuropsychol. 2002 Jun;24(4):517-26. doi: 10.1076/jcen.24.4.517.1043. J Clin Exp Neuropsychol. 2002. PMID: 12187464 - Evidence for specific cognitive deficits in preclinical Huntington's disease.
Lawrence AD, Hodges JR, Rosser AE, Kershaw A, ffrench-Constant C, Rubinsztein DC, Robbins TW, Sahakian BJ. Lawrence AD, et al. Brain. 1998 Jul;121 ( Pt 7):1329-41. doi: 10.1093/brain/121.7.1329. Brain. 1998. PMID: 9679784 - Inhibitory control during smooth pursuit in Parkinson's disease and Huntington's disease.
Henderson T, Georgiou-Karistianis N, White O, Millist L, Williams DR, Churchyard A, Fielding J. Henderson T, et al. Mov Disord. 2011 Aug 15;26(10):1893-9. doi: 10.1002/mds.23757. Epub 2011 May 31. Mov Disord. 2011. PMID: 21630355 - Attentional impairments in Huntington's disease: A specific deficit for the executive conflict.
Maurage P, Heeren A, Lahaye M, Jeanjean A, Guettat L, Verellen-Dumoulin C, Halkin S, Billieux J, Constant E. Maurage P, et al. Neuropsychology. 2017 May;31(4):424-436. doi: 10.1037/neu0000321. Epub 2017 Feb 27. Neuropsychology. 2017. PMID: 28240935 - Visual attention and perception in patients with Huntington's disease: comparisons with other subcortical and cortical dementias.
Filoteo JV, Delis DC, Roman MJ, Demadura T, Ford E, Butters N, Salmon DP, Paulsen J, Shults CW, Swenson M, et al. Filoteo JV, et al. J Clin Exp Neuropsychol. 1995 Oct;17(5):654-67. doi: 10.1080/01688639508405156. J Clin Exp Neuropsychol. 1995. PMID: 8557807
Cited by
- Are you angry? Neural basis of impaired facial expression recognition in pre-manifest Huntington's.
Rosas HD, Lewis L, Connors N, Mercaldo ND, Nasr S. Rosas HD, et al. Parkinsonism Relat Disord. 2023 Apr;109:105289. doi: 10.1016/j.parkreldis.2023.105289. Epub 2023 Jan 20. Parkinsonism Relat Disord. 2023. PMID: 36948112 Free PMC article. - Deficient sustained attention to response task and P300 characteristics in early Huntington's disease.
Hart EP, Dumas EM, Reijntjes RH, van der Hiele K, van den Bogaard SJ, Middelkoop HA, Roos RA, van Dijk JG. Hart EP, et al. J Neurol. 2012 Jun;259(6):1191-8. doi: 10.1007/s00415-011-6334-0. Epub 2011 Dec 6. J Neurol. 2012. PMID: 22143614 Free PMC article. - [Neuropsychiatric aspects of Huntington chorea. Presentation of 2 cases and review of the literature].
Tost H, Schmitt A, Brassen S, Wendt CS, Braus DF. Tost H, et al. Nervenarzt. 2004 Mar;75(3):258-66. doi: 10.1007/s00115-003-1594-2. Nervenarzt. 2004. PMID: 15021927 Review. German. - Neuropsychological assessment of dementia.
Salmon DP, Bondi MW. Salmon DP, et al. Annu Rev Psychol. 2009;60:257-82. doi: 10.1146/annurev.psych.57.102904.190024. Annu Rev Psychol. 2009. PMID: 18616392 Free PMC article. Review. - Home cage-based insights into motor learning and strategy adaptation in a Huntington disease mouse model.
Ramandi D, Sepers MD, Wang Z, Han B, Woodard CL, Murphy TH, Raymond LA. Ramandi D, et al. PLoS One. 2025 Feb 13;20(2):e0318663. doi: 10.1371/journal.pone.0318663. eCollection 2025. PLoS One. 2025. PMID: 39946413 Free PMC article.
MeSH terms
LinkOut - more resources
Full Text Sources
Medical