Evolving concepts in the pathogenesis of postinjury multiple organ failure - PubMed (original) (raw)
Review
Evolving concepts in the pathogenesis of postinjury multiple organ failure
F A Moore et al. Surg Clin North Am. 1995 Apr.
Abstract
Early epidemiologic studies concluded that infection with systemic sepsis was the common pathway for the development of ARDS and eventual MOF. As a consequence, research investigation from 1977 to 1987 focused on later clinical events (e.g., immunosuppression, persistent hypercatabolism, and bacterial translocation). Now, it is believed that an initial massive traumatic insult can create severe SIRS independent of infection (one-hit model). Alternatively, a less severe traumatic insult can create an inflammatory environment (i.e., primes the host) such that a later, otherwise innocuous, secondary inflammatory insult precipitates severe SIRS (two-hit model). As a result of these newer inflammatory models, research interest during the last 5 years has shifted to investigating earlier clinical events (e.g., unrecognized flow-dependent oxygen consumption, ischemia/reperfusion, and priming/activation of the inflammatory response).
Similar articles
- Postinjury multiple organ failure: role of extrathoracic injury and sepsis in adult respiratory distress syndrome.
Moore FA, Moore EE, Read RA. Moore FA, et al. New Horiz. 1993 Nov;1(4):538-49. New Horiz. 1993. PMID: 8087574 Review. - Neutrophil priming and activation in the pathogenesis of postinjury multiple organ failure.
Partrick DA, Moore FA, Moore EE, Barnett CC Jr, Silliman CC. Partrick DA, et al. New Horiz. 1996 May;4(2):194-210. New Horiz. 1996. PMID: 8774796 - Multiple organ failure. How valid is the "two hit" model?
Saadia R, Schein M. Saadia R, et al. J Accid Emerg Med. 1999 May;16(3):163-6; discussion 166-7. doi: 10.1136/emj.16.3.163. J Accid Emerg Med. 1999. PMID: 10353038 Free PMC article. Review. - The postischemic gut serves as a priming bed for circulating neutrophils that provoke multiple organ failure.
Moore EE, Moore FA, Franciose RJ, Kim FJ, Biffl WL, Banerjee A. Moore EE, et al. J Trauma. 1994 Dec;37(6):881-7. doi: 10.1097/00005373-199412000-00002. J Trauma. 1994. PMID: 7996599 Review. - Decreased progression of postinjury lung dysfunction to the acute respiratory distress syndrome and multiple organ failure.
Ciesla DJ, Moore EE, Johnson JL, Cothren CC, Banerjee A, Burch JM, Sauaia A. Ciesla DJ, et al. Surgery. 2006 Oct;140(4):640-7; discussion 647-8. doi: 10.1016/j.surg.2006.06.015. Epub 2006 Aug 30. Surgery. 2006. PMID: 17011912
Cited by
- Electrophoretic determination of the myosin/actin ratio in the diagnosis of critical illness myopathy.
Stibler H, Edström L, Ahlbeck K, Remahl S, Ansved T. Stibler H, et al. Intensive Care Med. 2003 Sep;29(9):1515-27. doi: 10.1007/s00134-003-1894-9. Epub 2003 Aug 12. Intensive Care Med. 2003. PMID: 12915938 Clinical Trial. - A review of metabolic staging in severely injured patients.
Aller MA, Arias JI, Alonso-Poza A, Arias J. Aller MA, et al. Scand J Trauma Resusc Emerg Med. 2010 May 17;18:27. doi: 10.1186/1757-7241-18-27. Scand J Trauma Resusc Emerg Med. 2010. PMID: 20478066 Free PMC article. Review. - Late immune consequences of combat trauma: a review of trauma-related immune dysfunction and potential therapies.
Thompson KB, Krispinsky LT, Stark RJ. Thompson KB, et al. Mil Med Res. 2019 Apr 24;6(1):11. doi: 10.1186/s40779-019-0202-0. Mil Med Res. 2019. PMID: 31014397 Free PMC article. Review. - Interleukin-6 as inflammatory marker referring to multiple organ dysfunction syndrome in severely injured children.
Andruszkow H, Fischer J, Sasse M, Brunnemer U, Andruszkow JH, Gänsslen A, Hildebrand F, Frink M. Andruszkow H, et al. Scand J Trauma Resusc Emerg Med. 2014 Mar 3;22:16. doi: 10.1186/1757-7241-22-16. Scand J Trauma Resusc Emerg Med. 2014. PMID: 24589345 Free PMC article. - Procalcitonin and C-reactive protein during the early posttraumatic systemic inflammatory response syndrome.
Mimoz O, Benoist JF, Edouard AR, Assicot M, Bohuon C, Samii K. Mimoz O, et al. Intensive Care Med. 1998 Feb;24(2):185-8. doi: 10.1007/s001340050543. Intensive Care Med. 1998. PMID: 9539079
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
Research Materials