IPF1, a homeodomain-containing transactivator of the insulin gene - PubMed (original) (raw)
Comparative Study
IPF1, a homeodomain-containing transactivator of the insulin gene
H Ohlsson et al. EMBO J. 1993 Nov.
Abstract
We describe the cloning of insulin promoter factor 1 (IPF1), a homeodomain protein which in the adult mouse pancreas is selectively expressed in the beta-cells and which binds to and transactivates the insulin promoter. In embryos, IPF1 expression is initiated prior to hormone gene expression and is restricted to the dorsal and ventral walls of the primitive foregut at the positions where pancreas will later form. The pattern of IPF1 expression and its ability to stimulate insulin gene transcription suggest that IPF1 functions both in the regionalization of the primitive gut endoderm and in the maturation of the pancreatic beta-cell.
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References
- Gene. 1988 Jul 15;67(1):31-40 - PubMed
- Proc Natl Acad Sci U S A. 1988 Jun;85(12):4228-31 - PubMed
- Cell. 1988 Nov 4;55(3):519-29 - PubMed
- Proc Natl Acad Sci U S A. 1988 Dec;85(23):9037-41 - PubMed
- Genes Dev. 1988 Dec;2(12A):1513-6 - PubMed
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