Prefrontal cortex regulates burst firing and transmitter release in rat mesolimbic dopamine neurons studied in vivo - PubMed (original) (raw)

Prefrontal cortex regulates burst firing and transmitter release in rat mesolimbic dopamine neurons studied in vivo

S Murase et al. Neurosci Lett. 1993.

Abstract

The influence of the medial prefrontal cortex (PFC) on mesolimbic dopamine activity was studied with electrophysiological techniques and in vivo voltammetry in the chloral hydrate-anesthetized male rat. Glutamate injected into the PFC selectively increased burst firing of single dopamine cells in the ventral tegmental area and enhanced the release of dopamine from nerve terminals in the nucleus accumbens. PFC injection of the local anesthetic lidocaine produced the opposite effects on burst firing and terminal release. This selective modulation of the dynamic activity of mesolimbic dopamine neurons by the prefrontal cortex might be important in motivation, learning and schizophrenia.

PubMed Disclaimer

Similar articles

• Is the release of dopamine from medial prefrontal cortex modulated by presynaptic receptors? Comparison with nigrostriatal and mesolimbic terminals.
  Cubeddu LX, Hoffmann IS, Talmaciu RK. Cubeddu LX, et al. Ann N Y Acad Sci. 1990;604:452-61. doi: 10.1111/j.1749-6632.1990.tb32011.x. Ann N Y Acad Sci. 1990. PMID: 2171402
• Neurotransmitters and prefrontal cortex-limbic system interactions: implications for plasticity and psychiatric disorders.
  Del Arco A, Mora F. Del Arco A, et al. J Neural Transm (Vienna). 2009 Aug;116(8):941-52. doi: 10.1007/s00702-009-0243-8. Epub 2009 May 28. J Neural Transm (Vienna). 2009. PMID: 19475335 Review.
• Prefrontal cortex-nucleus accumbens interaction: in vivo modulation by dopamine and glutamate in the prefrontal cortex.
  Del Arco A, Mora F. Del Arco A, et al. Pharmacol Biochem Behav. 2008 Aug;90(2):226-35. doi: 10.1016/j.pbb.2008.04.011. Epub 2008 Apr 23. Pharmacol Biochem Behav. 2008. PMID: 18508116 Review.

Cited by

• Insulin in the ventral tegmental area reduces hedonic feeding and suppresses dopamine concentration via increased reuptake.
  Mebel DM, Wong JC, Dong YJ, Borgland SL. Mebel DM, et al. Eur J Neurosci. 2012 Aug;36(3):2336-46. doi: 10.1111/j.1460-9568.2012.08168.x. Epub 2012 Jun 20. Eur J Neurosci. 2012. PMID: 22712725 Free PMC article.
• Dopamine increases in striatum do not elicit craving in cocaine abusers unless they are coupled with cocaine cues.
  Volkow ND, Wang GJ, Telang F, Fowler JS, Logan J, Childress AR, Jayne M, Ma Y, Wong C. Volkow ND, et al. Neuroimage. 2008 Feb 1;39(3):1266-73. doi: 10.1016/j.neuroimage.2007.09.059. Epub 2007 Oct 11. Neuroimage. 2008. PMID: 18024160 Free PMC article.
• The role of rat medial frontal cortex in effort-based decision making.
  Walton ME, Bannerman DM, Rushworth MF. Walton ME, et al. J Neurosci. 2002 Dec 15;22(24):10996-1003. doi: 10.1523/JNEUROSCI.22-24-10996.2002. J Neurosci. 2002. PMID: 12486195 Free PMC article.
• The infralimbic cortex bidirectionally modulates mesolimbic dopamine neuron activity via distinct neural pathways.
  Patton MH, Bizup BT, Grace AA. Patton MH, et al. J Neurosci. 2013 Oct 23;33(43):16865-73. doi: 10.1523/JNEUROSCI.2449-13.2013. J Neurosci. 2013. PMID: 24155293 Free PMC article.
• The role of dopamine in Huntington's disease.
  Cepeda C, Murphy KP, Parent M, Levine MS. Cepeda C, et al. Prog Brain Res. 2014;211:235-54. doi: 10.1016/B978-0-444-63425-2.00010-6. Prog Brain Res. 2014. PMID: 24968783 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Miscellaneous

  • NCI CPTAC Assay Portal