Regional cerebral blood flow in depression measured by positron emission tomography: the relationship with clinical dimensions - PubMed (original) (raw)
Review
Regional cerebral blood flow in depression measured by positron emission tomography: the relationship with clinical dimensions
C J Bench et al. Psychol Med. 1993 Aug.
Abstract
We have previously reported focal abnormalities of regional cerebral blood flow (rCBF) in a group of 33 patients with major depression. This report, on an extended sample of 40 patients who demonstrated identical regional deficits to those previously described, examines the relationships between depressive symptoms and patterns of rCBF. Patients' symptom ratings were subjected to factor analysis, producing a three-factor solution. The scores for these three factors, which corresponded to recognizable dimensions of depressive illness, were then correlated with rCBF. The first factor had high loadings for anxiety and correlated positively with rCBF in the posterior cingulate cortex and inferior parietal lobule bilaterally. The second factor had high loadings for psychomotor retardation and depressed mood and correlated negatively with rCBF in the left dorsolateral prefrontal cortex and left angular gyrus. The third factor had a high loading for cognitive performance and correlated positively with rCBF in the left medial prefrontal cortex. These data indicate that symptomatic specificity may be ascribed to regional functional deficits in major depressive illness.
Similar articles
- Hypofrontality and negative symptoms in major depressive disorder.
Galynker II, Cai J, Ongseng F, Finestone H, Dutta E, Serseni D. Galynker II, et al. J Nucl Med. 1998 Apr;39(4):608-12. J Nucl Med. 1998. PMID: 9544664 - Relationship between regional cerebral blood flow and separate symptom clusters of major depression: a single photon emission computed tomography study using statistical parametric mapping.
Périco CA, Skaf CR, Yamada A, Duran F, Buchpiguel CA, Castro CC, Soares JC, Busatto GF. Périco CA, et al. Neurosci Lett. 2005 Aug 26;384(3):265-70. doi: 10.1016/j.neulet.2005.04.088. Neurosci Lett. 2005. PMID: 15921853 Clinical Trial. - Cerebral blood flow during anxiety provocation.
Fredrikson M, Fischer H, Wik G. Fredrikson M, et al. J Clin Psychiatry. 1997;58 Suppl 16:16-21. J Clin Psychiatry. 1997. PMID: 9430505 Review. - Quantitative positron emission tomography and single photon emission computed tomography measurements of human cerebral blood flow.
Lagrèze HL, Levine RL. Lagrèze HL, et al. Am J Physiol Imaging. 1987;2(4):208-15. Am J Physiol Imaging. 1987. PMID: 3330454 Review.
Cited by
- Association between depression, anemia and physical activity using isotemporal substitution analysis.
Nam HK, Park J, Cho SI. Nam HK, et al. BMC Public Health. 2023 Nov 13;23(1):2236. doi: 10.1186/s12889-023-17117-1. BMC Public Health. 2023. PMID: 37957654 Free PMC article. - Reduced reward responsiveness in treatment resistant depression of middle-aged adults: Association with carotid artery stiffness and tetrahydrobiopterin.
Barhwal KK, Parida B, Pattnaik J, Rowlo P, Mahakud S, Patra S, Rao BN, Mahapatra B. Barhwal KK, et al. PLoS One. 2023 Aug 31;18(8):e0290784. doi: 10.1371/journal.pone.0290784. eCollection 2023. PLoS One. 2023. PMID: 37651359 Free PMC article. - Robotic transcranial magnetic stimulation in the treatment of depression: a pilot study.
Shin H, Jeong H, Ryu W, Lee G, Lee J, Kim D, Song IU, Chung YA, Lee S. Shin H, et al. Sci Rep. 2023 Aug 28;13(1):14074. doi: 10.1038/s41598-023-41044-1. Sci Rep. 2023. PMID: 37640754 Free PMC article. - COMT Val158Met Polymorphism Influences the Cerebral Blood Flow Changes Related to Psychomotor Retardation in Major Depressive Disorder.
Yin Y, Xie C, Zhang H, Zhang H, Zhang Z, Yuan Y. Yin Y, et al. Neuropsychiatr Dis Treat. 2022 Sep 25;18:2159-2169. doi: 10.2147/NDT.S379146. eCollection 2022. Neuropsychiatr Dis Treat. 2022. PMID: 36187559 Free PMC article. - A preliminary study on predictors of treatment response to repetitive transcranial magnetic stimulation in patients with treatment-resistant depression in Japan.
Ikawa H, Tochigi M, Noda Y, Oba H, Kaminaga T, Sakurai K, Ikebuchi E, Hayashi N, Kunugi H. Ikawa H, et al. Neuropsychopharmacol Rep. 2022 Dec;42(4):478-484. doi: 10.1002/npr2.12290. Epub 2022 Aug 30. Neuropsychopharmacol Rep. 2022. PMID: 36039823 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources