Regression in basal cell carcinoma: an immunohistochemical analysis - PubMed (original) (raw)
Comparative Study
Regression in basal cell carcinoma: an immunohistochemical analysis
M J Hunt et al. Br J Dermatol. 1994 Jan.
Abstract
Spontaneous regression of some cutaneous tumours is well recognized, and is thought to result from an immunological response to the tumour. Regression has previously been noted in basal cell carcinomas, but no studies defining the role of the immune response in the regression of this malignancy have been performed. We have examined 45 primary basal cell carcinomas (BCCs) (20 nodular, 25 superficial) and identified the cellular phenotypes and activation states of the cells infiltrating primary regressing and non-regressing BCCs, by immunocytochemistry. We have found a significantly increased number of CD3+ and CD4+ T cells infiltrating regressing compared with non-regressing tumours, and the expression of interleukin-2 receptor (an early activation marker for T cells) was also increased. There were no significant differences in class II major histocompatibility complex (MHC), CD1, or macrophage antigen expression in these groups. These findings suggest that activated CD4+ cytokine-secreting cells are important in the regression of BCCs.
Similar articles
- Spontaneous regression of human melanoma/nonmelanoma skin cancer: association with infiltrating CD4+ T cells.
Halliday GM, Patel A, Hunt MJ, Tefany FJ, Barnetson RS. Halliday GM, et al. World J Surg. 1995 May-Jun;19(3):352-8. doi: 10.1007/BF00299157. World J Surg. 1995. PMID: 7638987 - Cytokine profiles in spontaneously regressing basal cell carcinomas.
Wong DA, Bishop GA, Lowes MA, Cooke B, Barnetson RS, Halliday GM. Wong DA, et al. Br J Dermatol. 2000 Jul;143(1):91-8. doi: 10.1046/j.1365-2133.2000.03596.x. Br J Dermatol. 2000. PMID: 10886141 - CD4+ T lymphocyte infiltration correlates with regression of a UV-induced squamous cell carcinoma.
Patel A, Halliday GM, Barnetson RS. Patel A, et al. J Dermatol Sci. 1995 Jan;9(1):12-9. doi: 10.1016/0923-1811(94)00344-e. J Dermatol Sci. 1995. PMID: 7727352 - Folliculotropic T cells in regressive basal cell carcinoma of skin.
Lespi PJ, Gregorini SD. Lespi PJ, et al. Am J Dermatopathol. 2000 Feb;22(1):30-3. doi: 10.1097/00000372-200002000-00006. Am J Dermatopathol. 2000. PMID: 10698213 - Regression in skin tumours: a common phenomenon.
Barnetson RS, Halliday GM. Barnetson RS, et al. Australas J Dermatol. 1997 Jun;38 Suppl 1:S63-5. doi: 10.1111/j.1440-0960.1997.tb01013.x. Australas J Dermatol. 1997. PMID: 10994476 Review.
Cited by
- The Immune Microenvironment in Basal Cell Carcinoma.
Zilberg C, Lyons JG, Gupta R, Damian DL. Zilberg C, et al. Ann Dermatol. 2023 Aug;35(4):243-255. doi: 10.5021/ad.22.042. Ann Dermatol. 2023. PMID: 37550225 Free PMC article. Review. - Clinical and histopathological characteristics of primary and recurrent basal cell carcinoma: a retrospective study of the patients from a tertiary clinical centre in the northern Poland.
Płaszczyńska A, Skibiński R, Sławińska M, Biernat W, Lesiak A, Nowicki RJ, Sobjanek M. Płaszczyńska A, et al. Postepy Dermatol Alergol. 2022 Feb;39(1):126-131. doi: 10.5114/ada.2022.113806. Epub 2022 Feb 28. Postepy Dermatol Alergol. 2022. PMID: 35369621 Free PMC article. - Vaccination against PD-L1 with IO103 a Novel Immune Modulatory Vaccine in Basal Cell Carcinoma: A Phase IIa Study.
Jørgensen NG, Kaae J, Grauslund JH, Met Ö, Nielsen SL, Pedersen AW, Svane IM, Ehrnrooth E, Andersen MH, Zachariae C, Skov L. Jørgensen NG, et al. Cancers (Basel). 2021 Feb 22;13(4):911. doi: 10.3390/cancers13040911. Cancers (Basel). 2021. PMID: 33671555 Free PMC article. - [Surgical techniques in the treatment of basal cell carcinoma-a prospective investigation].
Kofler L, Häfner HM, Schulz C, Eichner M, Kofler K, Schnabl SM, Breuninger H. Kofler L, et al. Hautarzt. 2020 Dec;71(12):960-968. doi: 10.1007/s00105-020-04685-1. Hautarzt. 2020. PMID: 32930855 Free PMC article. Clinical Trial. German. - Regression of Periocular Basal Cell Carcinoma: A Report of Four Cases with Clinicopathologic Correlation.
Herwig-Carl MC, Loeffler KU. Herwig-Carl MC, et al. Ocul Oncol Pathol. 2020 Mar;6(2):107-114. doi: 10.1159/000501370. Epub 2019 Aug 28. Ocul Oncol Pathol. 2020. PMID: 32258018 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials