An African swine fever virus gene with similarity to the T-lymphocyte surface antigen CD2 mediates hemadsorption - PubMed (original) (raw)
Comparative Study
An African swine fever virus gene with similarity to the T-lymphocyte surface antigen CD2 mediates hemadsorption
M V Borca et al. Virology. 1994 Mar.
Abstract
An open reading frame, LMW8-DR, in the African swine fever virus (ASFV) genome possesses striking similarity to the lymphocyte membrane antigen CD2. All characterized CD2 domains, including the amino-terminal signal sequence, IgV, hinge, IgC2, stalk, transmembrane, and proline-rich carboxy cytoplasmic domains, are highly conserved in the ASFV gene. Critical residues for the binding of the lymphocyte function-associated antigen (LFA-3) and CD59 and for T-cell activation are also partially conserved. LMW8-DR is actively transcribed in ASFV-infected swine macrophages and Vero cells at late times in the infection cycle and Vero and COS cells transiently expressing the LMW8-DR open reading frame hemadsorbed swine red blood cells. The structural and functional similarities of LMW8-DR to CD2, a protein that is involved in cell-cell adhesion and immune response modulation, suggest a possible role in the pathogenesis of ASFV infection.
Similar articles
- African swine fever virus EP153R open reading frame encodes a glycoprotein involved in the hemadsorption of infected cells.
Galindo I, Almazán F, Bustos MJ, Viñuela E, Carrascosa AL. Galindo I, et al. Virology. 2000 Jan 20;266(2):340-51. doi: 10.1006/viro.1999.0080. Virology. 2000. PMID: 10639320 - A BIR motif containing gene of African swine fever virus, 4CL, is nonessential for growth in vitro and viral virulence.
Neilan JG, Lu Z, Kutish GF, Zsak L, Burrage TG, Borca MV, Carrillo C, Rock DL. Neilan JG, et al. Virology. 1997 Apr 14;230(2):252-64. doi: 10.1006/viro.1997.8481. Virology. 1997. PMID: 9143281 - Amino acid tandem repeats within a late viral gene define the central variable region of African swine fever virus.
Irusta PM, Borca MV, Kutish GF, Lu Z, Caler E, Carrillo C, Rock DL. Irusta PM, et al. Virology. 1996 Jun 1;220(1):20-7. doi: 10.1006/viro.1996.0281. Virology. 1996. PMID: 8659112 - Virus-host interactions in African swine fever: the attachment to cellular receptors.
Angulo A, Alcamí A, Viñuela E. Angulo A, et al. Arch Virol Suppl. 1993;7:169-83. doi: 10.1007/978-3-7091-9300-6_14. Arch Virol Suppl. 1993. PMID: 8219802 Review. - Murine CD2: structure, expression, and recognition of human LFA-3.
Jones WK, Sen J, Burakoff SJ. Jones WK, et al. Year Immunol. 1989-1990;6:95-111. Year Immunol. 1989. PMID: 2484460 Review. No abstract available.
Cited by
- Role of African Swine Fever Virus Proteins EP153R and EP402R in Reducing Viral Persistence in Blood and Virulence in Pigs Infected with BeninΔDP148R.
Petrovan V, Rathakrishnan A, Islam M, Goatley LC, Moffat K, Sanchez-Cordon PJ, Reis AL, Dixon LK. Petrovan V, et al. J Virol. 2022 Jan 12;96(1):e0134021. doi: 10.1128/JVI.01340-21. Epub 2021 Oct 13. J Virol. 2022. PMID: 34643433 Free PMC article. - A quadruple fluorescence quantitative PCR method for the identification of wild strains of african swine fever and gene-deficient strains.
Zuo X, Peng G, Xia Y, Xu L, Zhao Q, Zhu Y, Wang C, Liu Y, Zhao J, Wang H, Zou X. Zuo X, et al. Virol J. 2023 Jul 14;20(1):150. doi: 10.1186/s12985-023-02111-1. Virol J. 2023. PMID: 37452402 Free PMC article. - African swine fever virus infection of porcine aortic endothelial cells leads to inhibition of inflammatory responses, activation of the thrombotic state, and apoptosis.
Vallée I, Tait SW, Powell PP. Vallée I, et al. J Virol. 2001 Nov;75(21):10372-82. doi: 10.1128/JVI.75.21.10372-10382.2001. J Virol. 2001. PMID: 11581405 Free PMC article. - Thoughts on African Swine Fever Vaccines.
Rock DL. Rock DL. Viruses. 2021 May 20;13(5):943. doi: 10.3390/v13050943. Viruses. 2021. PMID: 34065425 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous