Effect of spleen cell populations on resolution of Cryptosporidium parvum infection in SCID mice - PubMed (original) (raw)

Effect of spleen cell populations on resolution of Cryptosporidium parvum infection in SCID mice

L E Perryman et al. Infect Immun. 1994 Apr.

Abstract

Persistent infection was established in SCID mice given 10(7) Cryptosporidium parvum oocysts. Nine groups of infected SCID mice were inoculated with 10(6), 10(5), or 10(4) total spleen cells, CD8-depleted spleen cells, or CD4-depleted spleen cells from naive BALB/c donors. Infection was significantly reduced in all treatment groups. The most profound effect occurred with spleen cell preparations containing CD4 T lymphocytes but depleted of CD8 T lymphocytes.

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References

    1. Nature. 1983 Feb 10;301(5900):527-30 - PubMed
    1. Immunol Rev. 1982;69:5-23 - PubMed
    1. Lancet. 1983 May 28;1(8335):1187-91 - PubMed
    1. J Immunol. 1983 Nov;131(5):2445-51 - PubMed
    1. Arch Intern Med. 1983 Dec;143(12):2269-75 - PubMed

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