Enhanced establishment of a virus carrier state in adult CD4+ T-cell-deficient mice - PubMed (original) (raw)

Enhanced establishment of a virus carrier state in adult CD4+ T-cell-deficient mice

M Battegay et al. J Virol. 1994 Jul.

Abstract

CD4+ T cells play an important role in regulating the immune response; their contribution to virus clearance is variable. Mice that lack CD4+ T cells (CD4-/- mice) and are therefore unable to produce neutralizing antibodies cleared viscero-lymphotropic lymphocytic choriomeningitis virus (LCMV) strain WE when infected intravenously with a low dose (2 x 10(2) PFU) because of an effective CD8+ cytotoxic T-cell (CTL) response. In contrast, infection with a high dose (2 x 10(6) PFU) of LCMV strain WE led to expansion of antiviral CTL, which disappeared in CD4-/- mice; in contrast, CD4+ T-cell-competent mice developed antiviral memory CTL. This exhaustion of specific CTL caused viral persistence in CD4-/- mice, whereas CD4+ T-cell-competent mice eliminated the virus. After infection of CD4-/- mice with the faster-replicating LCMV strain DOCILE, abrogation of CTL response and establishment of viral persistence developed after infection with a low dose (5 x 10(2) PFU), i.e., an about 100-fold lower dose than in CD(4+)-competent control mice. These results show that absence of T help enhances establishment of an LCMV carrier state in selected situations.

PubMed Disclaimer

References

    1. Transplant Rev. 1974;19(0):56-88 - PubMed
    1. Int Immunol. 1993 Oct;5(10):1193-8 - PubMed
    1. J Immunol. 1976 Nov;117(5 Pt 1):1495-502 - PubMed
    1. J Exp Med. 1977 May 1;145(5):1131-43 - PubMed
    1. Nature. 1978 Dec 21-28;276(5690):829-31 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources