Target determination of neurotransmitter phenotype in sympathetic neurons - PubMed (original) (raw)

Review

Target determination of neurotransmitter phenotype in sympathetic neurons

R Schotzinger et al. J Neurobiol. 1994 Jun.

Abstract

While the majority of sympathetic neurons are noradrenergic, a minority population are cholinergic. At least one population of cholinergic sympathetic neurons arises during development by a target-dependent conversion from an initial noradrenergic phenotype. Evidence for retrograde specification has been obtained from transplantation studies in which sympathetic neurons that normally express a noradrenergic phenotype throughout life were induced to innervate sweat glands, a target normally innervated by cholinergic sympathetic neurons. This was accomplished by transplanting footpad skin containing sweat gland primordia from early postnatal donor rats to the hairy skin region of host rats. The sympathetic neurons innervating the novel target decreased their expression of noradrenergic traits and developed choline acetyltransferase (ChAT) activity. In addition, many sweat gland-associated fibers acquired acetylcholinesterase (AChE) staining and VIP immunoreactivity. These studies indicate that sympathetic neurons in vivo alter their neurotransmitter phenotype in response to novel environmental signals and that sweat glands play a critical role in the cholinergic and peptidergic differentiation of the sympathetic neurons that innervate them. The sweat gland-derived cholinergic differentiation factor is distinct from leukemia inhibitory factor and ciliary neurotrophic factor, two well-characterized cytokines that alter the neurotransmitter properties of cultured sympathetic neurons in a similar fashion. Recent studies indicate that anterograde signalling is also important for the establishment of functional synapses in this system. We have found that the production of cholinergic differentiation activity by sweat glands requires sympathetic innervation, and the acquisition and maintenance of secretory competence by sweat glands depends upon functional cholinergic innervation.

PubMed Disclaimer

Similar articles

• Cholinergic phenotype developed by noradrenergic sympathetic neurons after innervation of a novel cholinergic target in vivo.
  Schotzinger RJ, Landis SC. Schotzinger RJ, et al. Nature. 1988 Oct 13;335(6191):637-9. doi: 10.1038/335637a0. Nature. 1988. PMID: 3262829
• CNTF and LIF are not required for the target-directed acquisition of cholinergic and peptidergic properties by sympathetic neurons in vivo.
  Francis NJ, Asmus SE, Landis SC. Francis NJ, et al. Dev Biol. 1997 Feb 1;182(1):76-87. doi: 10.1006/dbio.1996.8464. Dev Biol. 1997. PMID: 9073449
• Production of sweat gland cholinergic differentiation factor depends on innervation.
  Habecker BA, Tresser SJ, Rao MS, Landis SC. Habecker BA, et al. Dev Biol. 1995 Jan;167(1):307-16. doi: 10.1006/dbio.1995.1025. Dev Biol. 1995. PMID: 7851651
• Cell interactions that determine sympathetic neuron transmitter phenotype and the neurokines that mediate them.
  Rao MS, Landis SC. Rao MS, et al. J Neurobiol. 1993 Feb;24(2):215-32. doi: 10.1002/neu.480240208. J Neurobiol. 1993. PMID: 8095295 Review.
• Development of the cholinergic neurotransmitter phenotype in postganglionic sympathetic neurons.
  Ernsberger U, Rohrer H. Ernsberger U, et al. Cell Tissue Res. 1999 Sep;297(3):339-61. doi: 10.1007/s004410051363. Cell Tissue Res. 1999. PMID: 10460483 Review.

Cited by

• The sympathies of the body: functional organization and neuronal differentiation in the peripheral sympathetic nervous system.
  Ernsberger U, Deller T, Rohrer H. Ernsberger U, et al. Cell Tissue Res. 2021 Dec;386(3):455-475. doi: 10.1007/s00441-021-03548-y. Epub 2021 Nov 10. Cell Tissue Res. 2021. PMID: 34757495 Free PMC article. Review.
• A single cell transcriptomics map of paracrine networks in the intrinsic cardiac nervous system.
  Moss A, Robbins S, Achanta S, Kuttippurathu L, Turick S, Nieves S, Hanna P, Smith EH, Hoover DB, Chen J, Cheng ZJ, Ardell JL, Shivkumar K, Schwaber JS, Vadigepalli R. Moss A, et al. iScience. 2021 Jul 19;24(7):102713. doi: 10.1016/j.isci.2021.102713. eCollection 2021 Jul 23. iScience. 2021. PMID: 34337356 Free PMC article.
• Neuronal lineages derived from the nerve-associated Schwann cell precursors.
  Kameneva P, Kastriti ME, Adameyko I. Kameneva P, et al. Cell Mol Life Sci. 2021 Jan;78(2):513-529. doi: 10.1007/s00018-020-03609-5. Epub 2020 Aug 3. Cell Mol Life Sci. 2021. PMID: 32748156 Free PMC article. Review.
• How early media exposure may affect cognitive function: A review of results from observations in humans and experiments in mice.
  Christakis DA, Ramirez JSB, Ferguson SM, Ravinder S, Ramirez JM. Christakis DA, et al. Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):9851-9858. doi: 10.1073/pnas.1711548115. Proc Natl Acad Sci U S A. 2018. PMID: 30275319 Free PMC article. Review.
• Differential Innervation of Secretory Coils and Ducts in Human Eccrine Sweat Glands.
  Ouyang Z, Li HH, Zhang MJ, Xie ST, Cheng LH. Ouyang Z, et al. Chin Med J (Engl). 2018 Aug 20;131(16):1964-1968. doi: 10.4103/0366-6999.238142. Chin Med J (Engl). 2018. PMID: 30082528 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Wiley