DP and E2F proteins: components of a heterodimeric transcription factor implicated in cell cycle control - PubMed (original) (raw)
Review
DP and E2F proteins: components of a heterodimeric transcription factor implicated in cell cycle control
N B La Thangue. Curr Opin Cell Biol. 1994 Jun.
Abstract
In mammalian cells, DRTF1/E2F is a transcription factor widely believed to integrate cell-cycle progression with the transcription apparatus through its cyclical interactions with important regulators of the cell cycle, such as the retinoblastoma tumour-suppressor gene product, cyclins and cyclin-dependent kinases. Recently, a number of exciting developments have uncovered the heterodimeric nature of DRTF1/E2F by defining two distinct families of proteins, DP and E2F, which comprise its activity; efficient DNA-binding activity arises when a DP protein interacts with an E2F protein. Combinatorial interactions generate a surprising array of sequence-specific heterodimers, a diversity that is probably necessary to enable different cell cycle regulating proteins to integrate their activities with transcription.
Similar articles
- Functional conservation of the cell cycle-regulating transcription factor DRTF1/E2F and its pathway of control in Drosophila melanogaster.
Hao XF, Alphey L, Bandara LR, Lam EW, Glover D, La Thangue NB. Hao XF, et al. J Cell Sci. 1995 Sep;108 ( Pt 9):2945-54. doi: 10.1242/jcs.108.9.2945. J Cell Sci. 1995. PMID: 8537434 - DP and E2F proteins: coordinating transcription with cell cycle progression.
Lam EW, La Thangue NB. Lam EW, et al. Curr Opin Cell Biol. 1994 Dec;6(6):859-66. doi: 10.1016/0955-0674(94)90057-4. Curr Opin Cell Biol. 1994. PMID: 7880534 Review. - Molecular characterization of Xenopus laevis DP proteins.
Girling R, Bandara LR, Ormondroyd E, Lam EW, Kotecha S, Mohun T, La Thangue NB. Girling R, et al. Mol Biol Cell. 1994 Oct;5(10):1081-92. doi: 10.1091/mbc.5.10.1081. Mol Biol Cell. 1994. PMID: 7865876 Free PMC article. - DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle control.
La Thangue NB. La Thangue NB. Trends Biochem Sci. 1994 Mar;19(3):108-14. doi: 10.1016/0968-0004(94)90202-x. Trends Biochem Sci. 1994. PMID: 8203017 Review.
Cited by
- Distinct tumor-TAM interactions in IDH-stratified glioma microenvironments unveiled by single-cell and spatial transcriptomics.
Motevasseli M, Darvishi M, Khoshnevisan A, Zeinalizadeh M, Saffar H, Bayat S, Najafi A, Abbaspour MJ, Mamivand A, Olson SB, Tabrizi M. Motevasseli M, et al. Acta Neuropathol Commun. 2024 Aug 16;12(1):133. doi: 10.1186/s40478-024-01837-5. Acta Neuropathol Commun. 2024. PMID: 39148129 Free PMC article. - Effect of Upregulation of Transcription Factor TFDP1 Binding Promoter Activity Due to RBP4 g.36491960G>C Mutation on the Proliferation of Goat Granulosa Cells.
Liu Y, Guo S, He X, Jiang Y, Hong Q, Lan R, Chu M. Liu Y, et al. Cells. 2022 Jul 8;11(14):2148. doi: 10.3390/cells11142148. Cells. 2022. PMID: 35883591 Free PMC article. - An E2F5-TFDP1-BRG1 Complex Mediates Transcriptional Activation of MYCN in Hepatocytes.
Fan Z, Kong M, Miao X, Guo Y, Ren H, Wang J, Wang S, Tang N, Shang L, Zhu Z, Liu H, Zhu W, Shi X. Fan Z, et al. Front Cell Dev Biol. 2021 Oct 22;9:742319. doi: 10.3389/fcell.2021.742319. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34746136 Free PMC article. - TFDP3 as E2F Unique Partner, Has Crucial Roles in Cancer Cells and Testis.
Huang J, Wang Y, Liu J, Chu M, Wang Y. Huang J, et al. Front Oncol. 2021 Oct 20;11:742462. doi: 10.3389/fonc.2021.742462. eCollection 2021. Front Oncol. 2021. PMID: 34745961 Free PMC article. Review. - E2F1: Cause and Consequence of DNA Replication Stress.
Fouad S, Hauton D, D'Angiolella V. Fouad S, et al. Front Mol Biosci. 2021 Feb 16;7:599332. doi: 10.3389/fmolb.2020.599332. eCollection 2020. Front Mol Biosci. 2021. PMID: 33665206 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources