Lamellipodia architecture: actin filament turnover and the lateral flow of actin filaments during motility - PubMed (original) (raw)
Review
Lamellipodia architecture: actin filament turnover and the lateral flow of actin filaments during motility
J V Small. Semin Cell Biol. 1994 Jun.
Abstract
Consideration of the arrangement of actin filaments in the lamellipodia of crawling cells indicates that, in addition to a rearward flow of the actin cytoskeleton due to treadmilling, there is a lateral flow of filaments in both directions. The existence of such a lateral flow of actin filaments is supported by observation of the lateral movement of actin filament bundles in fibroblasts and by fluorescence photoactivation data. In addition to explaining the formation, dispersal and lateral movement of filament bundles, lateral filament flow could add a further velocity component to the centripetal flow of cytoplasm. As such, lateral filament flow may explain the discrepancies in the rates of the rearward flow of actin, cytoplasmic materials and dorsal particles.
Similar articles
- On the mechanisms of cortical actin flow and its role in cytoskeletal organisation of fibroblasts.
Heath JP, Holifield BF. Heath JP, et al. Symp Soc Exp Biol. 1993;47:35-56. Symp Soc Exp Biol. 1993. PMID: 8165576 Review. - Actin and cell movement.
Small JV, Rohlfs A, Herzog M. Small JV, et al. Symp Soc Exp Biol. 1993;47:57-71. Symp Soc Exp Biol. 1993. PMID: 8165579 - Mechanism of lateral movement of filopodia and radial actin bundles across neuronal growth cones.
Oldenbourg R, Katoh K, Danuser G. Oldenbourg R, et al. Biophys J. 2000 Mar;78(3):1176-82. doi: 10.1016/S0006-3495(00)76675-6. Biophys J. 2000. PMID: 10692307 Free PMC article. - Identification of novel graded polarity actin filament bundles in locomoting heart fibroblasts: implications for the generation of motile force.
Cramer LP, Siebert M, Mitchison TJ. Cramer LP, et al. J Cell Biol. 1997 Mar 24;136(6):1287-305. doi: 10.1083/jcb.136.6.1287. J Cell Biol. 1997. PMID: 9087444 Free PMC article. - Cell locomotion: new research tests old ideas on membrane and cytoskeletal flow.
Heath JP, Holifield BF. Heath JP, et al. Cell Motil Cytoskeleton. 1991;18(4):245-57. doi: 10.1002/cm.970180402. Cell Motil Cytoskeleton. 1991. PMID: 2049790 Review.
Cited by
- Loss of cofilin 1 disturbs actin dynamics, adhesion between enveloping and deep cell layers and cell movements during gastrulation in zebrafish.
Lin CW, Yen ST, Chang HT, Chen SJ, Lai SL, Liu YC, Chan TH, Liao WL, Lee SJ. Lin CW, et al. PLoS One. 2010 Dec 22;5(12):e15331. doi: 10.1371/journal.pone.0015331. PLoS One. 2010. PMID: 21203473 Free PMC article. - Continuous taurocholic acid exposure promotes esophageal squamous cell carcinoma progression due to reduced cell loss resulting from enhanced vascular development.
Sato S, Yamamoto H, Mukaisho K, Saito S, Hattori T, Yamamoto G, Sugihara H. Sato S, et al. PLoS One. 2014 Feb 14;9(2):e88831. doi: 10.1371/journal.pone.0088831. eCollection 2014. PLoS One. 2014. PMID: 24551170 Free PMC article. - Mathematics of cell motility: have we got its number?
Mogilner A. Mogilner A. J Math Biol. 2009 Jan;58(1-2):105-34. doi: 10.1007/s00285-008-0182-2. Epub 2008 May 7. J Math Biol. 2009. PMID: 18461331 Free PMC article. Review. - CD2AP links cortactin and capping protein at the cell periphery to facilitate formation of lamellipodia.
Zhao J, Bruck S, Cemerski S, Zhang L, Butler B, Dani A, Cooper JA, Shaw AS. Zhao J, et al. Mol Cell Biol. 2013 Jan;33(1):38-47. doi: 10.1128/MCB.00734-12. Epub 2012 Oct 22. Mol Cell Biol. 2013. PMID: 23090967 Free PMC article. - Mechanism of filopodia initiation by reorganization of a dendritic network.
Svitkina TM, Bulanova EA, Chaga OY, Vignjevic DM, Kojima S, Vasiliev JM, Borisy GG. Svitkina TM, et al. J Cell Biol. 2003 Feb 3;160(3):409-21. doi: 10.1083/jcb.200210174. J Cell Biol. 2003. PMID: 12566431 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Research Materials