The Ikaros gene is required for the development of all lymphoid lineages - PubMed (original) (raw)
The Ikaros gene is required for the development of all lymphoid lineages
K Georgopoulos et al. Cell. 1994.
Abstract
The Ikaros gene encodes a family of early hematopoietic- and lymphocyte-restricted transcription factors. Mice homozygous for a germline mutation in the Ikaros DNA-binding domain lack not only T and B lymphocytes and natural killer cells but also their earliest defined progenitors. In contrast, the erythroid and myeloid lineages were intact in these mutant mice. We propose that Ikaros promotes differentiation of pluripotential hematopoietic stem cell(s) into the lymphocyte pathways. In the absence of a functional Ikaros gene, these stem cells are exclusively diverted into the erythroid and myeloid lineages.
Similar articles
- Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation.
Morgan B, Sun L, Avitahl N, Andrikopoulos K, Ikeda T, Gonzales E, Wu P, Neben S, Georgopoulos K. Morgan B, et al. EMBO J. 1997 Apr 15;16(8):2004-13. doi: 10.1093/emboj/16.8.2004. EMBO J. 1997. PMID: 9155026 Free PMC article. - Ikaros isoform x is selectively expressed in myeloid differentiation.
Payne KJ, Huang G, Sahakian E, Zhu JY, Barteneva NS, Barsky LW, Payne MA, Crooks GM. Payne KJ, et al. J Immunol. 2003 Mar 15;170(6):3091-8. doi: 10.4049/jimmunol.170.6.3091. J Immunol. 2003. PMID: 12626565 - Cell-autonomous defects in dendritic cell populations of Ikaros mutant mice point to a developmental relationship with the lymphoid lineage.
Wu L, Nichogiannopoulou A, Shortman K, Georgopoulos K. Wu L, et al. Immunity. 1997 Oct;7(4):483-92. doi: 10.1016/s1074-7613(00)80370-2. Immunity. 1997. PMID: 9354469 - Stem cells, clonal progenitors, and commitment to the three lymphocyte lineages: T, B, and NK cells.
Weissman IL. Weissman IL. Immunity. 1994 Oct;1(7):529-31. doi: 10.1016/1074-7613(94)90042-6. Immunity. 1994. PMID: 7600281 Review. No abstract available. - The role of the Ikaros gene in lymphocyte development and homeostasis.
Georgopoulos K, Winandy S, Avitahl N. Georgopoulos K, et al. Annu Rev Immunol. 1997;15:155-76. doi: 10.1146/annurev.immunol.15.1.155. Annu Rev Immunol. 1997. PMID: 9143685 Review.
Cited by
- Ikaros: master of hematopoiesis, agent of leukemia.
Davis KL. Davis KL. Ther Adv Hematol. 2011 Dec;2(6):359-68. doi: 10.1177/2040620711412419. Ther Adv Hematol. 2011. PMID: 23556102 Free PMC article. - NK Cell Development in Times of Innate Lymphoid Cell Diversity.
Stokic-Trtica V, Diefenbach A, Klose CSN. Stokic-Trtica V, et al. Front Immunol. 2020 Jul 8;11:813. doi: 10.3389/fimmu.2020.00813. eCollection 2020. Front Immunol. 2020. PMID: 32733432 Free PMC article. Review. - The Ikaros transcription factor regulates responsiveness to IL-12 and expression of IL-2 receptor alpha in mature, activated CD8 T cells.
Clambey ET, Collins B, Young MH, Eberlein J, David A, Kappler JW, Marrack P. Clambey ET, et al. PLoS One. 2013;8(2):e57435. doi: 10.1371/journal.pone.0057435. Epub 2013 Feb 26. PLoS One. 2013. PMID: 23483882 Free PMC article. - NKR-P1 biology: from prototype to missing self.
Mesci A, Ljutic B, Makrigiannis AP, Carlyle JR. Mesci A, et al. Immunol Res. 2006;35(1-2):13-26. doi: 10.1385/IR:35:1:13. Immunol Res. 2006. PMID: 17003506 Review. - An essential role for the hematopoietic transcription factor Ikaros in hypothalamic-pituitary-mediated somatic growth.
Ezzat S, Mader R, Fischer S, Yu S, Ackerley C, Asa SL. Ezzat S, et al. Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2214-9. doi: 10.1073/pnas.0508565103. Epub 2006 Feb 7. Proc Natl Acad Sci U S A. 2006. PMID: 16467156 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases