Infrequent stromal expression of gelatinase A and intact basement membrane in intraductal neoplasms of the pancreas - PubMed (original) (raw)

Comparative Study

. 1994 Nov;107(5):1488-95.

doi: 10.1016/0016-5085(94)90554-1.

Affiliations

• PMID: 7926512
• DOI: 10.1016/0016-5085(94)90554-1

Comparative Study

Infrequent stromal expression of gelatinase A and intact basement membrane in intraductal neoplasms of the pancreas

K Satoh et al. Gastroenterology. 1994 Nov.

Abstract

Background/aims: Basement membrane disruption is a characteristic of invasive carcinoma. Gelatinases (also called type IV collagenases) that degrade type IV collagen are believed to play an important role in tumor invasion and metastasis. Intraductal neoplasm (IDN) of the pancreas is a unique tumor that grows intraductally with an infrequent stromal invasion. However, in IDN, basement membrane anomaly and gelatinase expression have not been clarified. The aim of this study was to examine the relationships between basement membrane disruption and the expression of gelatinase A in relation to the biological behavior of IDN or pancreatic duct cell carcinoma (DCC).

Methods: Disruption of basement membrane and expression of gelatinase A were immunohistochemically investigated in 14 cases of IDN and 16 cases of DCC.

Results: Basement membrane was intact in all cases of IDN, whereas focal to severe disruption was observed in DCC. Stromal expression of gelatinase A was higher in DCC than in IDN, and the intensity of expression was related to the degree of disruption of the basement membrane in DCC.

Conclusions: Stromal expression of gelatinase A and disruption of basement membrane, common characteristics of invasive cancer, were not prominent in IDN. This may be related to the benign biological behavior of IDN.

PubMed Disclaimer

Similar articles

• Expression of type IV collagen and its degrading enzymes in squamous cell carcinoma of lung.
  Nakagawa H, Yagihashi S. Nakagawa H, et al. Jpn J Cancer Res. 1994 Sep;85(9):934-8. doi: 10.1111/j.1349-7006.1994.tb02971.x. Jpn J Cancer Res. 1994. PMID: 7961122 Free PMC article.
• Basement membrane patterns, gelatinase A and tissue inhibitor of metalloproteinase-2 expressions, and stromal fibrosis during the development of peripheral lung adenocarcinoma.
  Kitamura H, Oosawa Y, Kawano N, Kameda Y, Hayashi H, Nakatani Y, Udaka N, Ito T, Miyazaki K. Kitamura H, et al. Hum Pathol. 1999 Mar;30(3):331-8. doi: 10.1016/s0046-8177(99)90013-8. Hum Pathol. 1999. PMID: 10088553
• [Remodeling of basement membrane in association with cancer invasion].
  Nakano S, Tsuruta J, Iyama K. Nakano S, et al. Rinsho Byori. 2000 May;48(5):451-7. Rinsho Byori. 2000. PMID: 10892294 Review. Japanese.
• Membrane-type matrix metalloproteinases (MT-MMPs) in tumor metastasis.
  Sato H, Seiki M. Sato H, et al. J Biochem. 1996 Feb;119(2):209-15. doi: 10.1093/oxfordjournals.jbchem.a021223. J Biochem. 1996. PMID: 8882706 Review.

Cited by

• Up-regulation of MSX2 enhances the malignant phenotype and is associated with twist 1 expression in human pancreatic cancer cells.
  Satoh K, Hamada S, Kimura K, Kanno A, Hirota M, Umino J, Fujibuchi W, Masamune A, Tanaka N, Miura K, Egawa S, Motoi F, Unno M, Vonderhaar BK, Shimosegawa T. Satoh K, et al. Am J Pathol. 2008 Apr;172(4):926-39. doi: 10.2353/ajpath.2008.070346. Epub 2008 Mar 18. Am J Pathol. 2008. PMID: 18349132 Free PMC article.
• Transforming growth factor beta 1 and metalloproteinase-9 overexpression in colorectal cancer (CC) and adenoma.
  Daniel P, Wagrowska-Danilewicz M, Danilewicz M, Stasikowska O, Malecka-Panas E. Daniel P, et al. Int J Colorectal Dis. 2007 Oct;22(10):1165-72. doi: 10.1007/s00384-007-0296-9. Epub 2007 Mar 30. Int J Colorectal Dis. 2007. PMID: 17394006
• Histopathological study of intraductal papillary mucinous tumor of the pancreas: special reference to the roles of Survivin and p53 in tumorigenesis of IPMT.
  Jinfeng M, Kimura W, Sakurai F, Moriya T, Takeshita A, Hirai I. Jinfeng M, et al. Int J Gastrointest Cancer. 2002;32(2-3):73-81. doi: 10.1385/IJGC:32:2-3:73. Int J Gastrointest Cancer. 2002. PMID: 12794243
• Human macrophage metalloelastase worsens the prognosis of pancreatic cancer.
  Balaz P, Friess H, Kondo Y, Zhu Z, Zimmermann A, Büchler MW. Balaz P, et al. Ann Surg. 2002 Apr;235(4):519-27. doi: 10.1097/00000658-200204000-00010. Ann Surg. 2002. PMID: 11923608 Free PMC article.
• Gelatinase (MMP-2 and -9) expression in gastrointestinal malignancy.
  Parsons SL, Watson SA, Collins HM, Griffin NR, Clarke PA, Steele RJ. Parsons SL, et al. Br J Cancer. 1998 Dec;78(11):1495-502. doi: 10.1038/bjc.1998.712. Br J Cancer. 1998. PMID: 9836483 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Medical

  • MedlinePlus Health Information