Expression of the mucosal homing receptor alpha 4 beta 7 in malignant lymphomatous polyposis of the intestine - PubMed (original) (raw)
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Expression of the mucosal homing receptor alpha 4 beta 7 in malignant lymphomatous polyposis of the intestine
S T Pals et al. Gastroenterology. 1994 Nov.
Abstract
Recent studies have identified the integrin alpha 4 beta 7 as a mucosal homing receptor that mediates lymphocyte migration to the intestinal mucosa by binding to MAd-CAM-1, which is a vascular recognition molecule (adressin) selectively expressed on mucosal endothelium. The expression of the alpha 4 beta 7 mucosal homing receptor was studied in eight cases of malignant lymphomatous polyposis (MLP). This unusual presentation of non-Hodgkin's lymphoma of mantle cell type is characterized by multifocal lymphomatous involvement of the gastrointestinal tract. Unlike nodal mantle cell lymphomas, cases of MLP showed expression of alpha 4 beta 7, suggesting that this homing receptor plays an important role in determining the characteristic mucosal dissemination pattern of MLP.
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