The phosphorylation of stathmin by MAP kinase - PubMed (original) (raw)

. 1993 Nov:127-128:151-6.

doi: 10.1007/BF01076766.

Affiliations

• PMID: 7935347
• DOI: 10.1007/BF01076766

The phosphorylation of stathmin by MAP kinase

I A Leighton et al. Mol Cell Biochem. 1993 Nov.

Abstract

Stathmin, a ubiquitous cytosolic phosphoprotein which may play a role in integrating the effects of diverse signals regulating proliferation, differentiation and other cell functions, was found to be phosphorylated rapidly and stoichiometrically by mitogen-activated protein (MAP) kinase in vitro. Ser-25 was identified as the major site and Ser-38 as a minor site of phosphorylation, while the p42 and p44 isoforms of MAP kinase were the only significant stathmin kinases detected in PC12 cells after stimulation by nerve growth factor (NGF). The results suggest that MAP kinases are the enzymes responsible for increasing the level of phosphorylation of Ser-25, which has been observed previously in PC12 cells following stimulation by NGF.

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