A positive feedback loop coordinates growth and patterning in the vertebrate limb - PubMed (original) (raw)
. 1994 Oct 13;371(6498):609-12.
doi: 10.1038/371609a0.
Affiliations
- PMID: 7935794
- DOI: 10.1038/371609a0
A positive feedback loop coordinates growth and patterning in the vertebrate limb
L Niswander et al. Nature. 1994.
Abstract
Limb development depends on signals from the apical ectodermal ridge and underlying mesenchyme. Fibroblast growth factor (FGF) can replace the ridge and, because Fgf4 RNA is localized to the mouse posterior ridge, we proposed that FGF4 is the endogenous ridge signal. Ridge signals control limb outgrowth and maintain the zone of polarizing activity (ZPA) at the limb posterior margin, which is important in limb pattering: a ZPA graft to limb anterior mesenchyme causes cell respecification and mirror-image duplications. Sonic hedgehog (SHH) has polarizing activity, and Shh RNA co-localizes with ZPA activity, suggesting SHH is the endogenous polarizing signal. We have investigated the molecular regulation of Fgf4 and Shh expression. We report here that Fgf4 expression in the ridge can be regulated by Shh-expressing cells. Moreover, Shh expression in mesenchyme can be activated by FGF4 in combination with retinoic acid. Once induced, Shh expression can be maintained by FGF4 alone, thus establishing a positive feedback loop between ZPA and ridge.
Comment in
- Developmental biology. The limb bud--Part two.
Maden M. Maden M. Nature. 1994 Oct 13;371(6498):560-1. doi: 10.1038/371560a0. Nature. 1994. PMID: 7935787 No abstract available.
Similar articles
- Expression of genes encoding bone morphogenetic proteins and sonic hedgehog in talpid (ta3) limb buds: their relationships in the signalling cascade involved in limb patterning.
Francis-West PH, Robertson KE, Ede DA, Rodriguez C, Izpisúa-Belmonte JC, Houston B, Burt DW, Gribbin C, Brickell PM, Tickle C. Francis-West PH, et al. Dev Dyn. 1995 Jun;203(2):187-97. doi: 10.1002/aja.1002030207. Dev Dyn. 1995. PMID: 7655081 - Constitutive activation of sonic hedgehog signaling in the chicken mutant talpid(2): Shh-independent outgrowth and polarizing activity.
Caruccio NC, Martinez-Lopez A, Harris M, Dvorak L, Bitgood J, Simandl BK, Fallon JF. Caruccio NC, et al. Dev Biol. 1999 Aug 1;212(1):137-49. doi: 10.1006/dbio.1999.9321. Dev Biol. 1999. PMID: 10419691 - Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function.
Chiang C, Litingtung Y, Harris MP, Simandl BK, Li Y, Beachy PA, Fallon JF. Chiang C, et al. Dev Biol. 2001 Aug 15;236(2):421-35. doi: 10.1006/dbio.2001.0346. Dev Biol. 2001. PMID: 11476582 - [Control of the positioning of the vertebrate limb axes during development].
Catala M. Catala M. Morphologie. 2000 Jun;84(265):17-23. Morphologie. 2000. PMID: 11048294 Review. French. - Function of FGF-4 in limb development.
Niswander L, Tickle C, Vogel A, Martin G. Niswander L, et al. Mol Reprod Dev. 1994 Sep;39(1):83-8; discussion 88-9. doi: 10.1002/mrd.1080390113. Mol Reprod Dev. 1994. PMID: 7999365 Review.
Cited by
- Retinoic acid breakdown is required for proximodistal positional identity during amphibian limb regeneration.
Duerr TJ, Miller M, Kumar S, Bakr D, Griffiths JR, Gautham AK, Douglas D, Voss SR, Monaghan JR. Duerr TJ, et al. bioRxiv [Preprint]. 2024 Aug 9:2024.08.07.607055. doi: 10.1101/2024.08.07.607055. bioRxiv. 2024. PMID: 39149228 Free PMC article. Preprint. - Skeletal dysmorphology and mineralization defects in Fgf20 KO mice.
Dlugosova S, Spoutil F, Madureira Trufen CE, Melike Ogan B, Prochazkova M, Fedosieieva O, Nickl P, Aranaz Novaliches G, Sedlacek R, Prochazka J. Dlugosova S, et al. Front Endocrinol (Lausanne). 2024 Jul 26;15:1286365. doi: 10.3389/fendo.2024.1286365. eCollection 2024. Front Endocrinol (Lausanne). 2024. PMID: 39129916 Free PMC article. - Fgf signalling triggers an intrinsic mesodermal timer that determines the duration of limb patterning.
Sedas Perez S, McQueen C, Stainton H, Pickering J, Chinnaiya K, Saiz-Lopez P, Placzek M, Ros MA, Towers M. Sedas Perez S, et al. Nat Commun. 2023 Sep 20;14(1):5841. doi: 10.1038/s41467-023-41457-6. Nat Commun. 2023. PMID: 37730682 Free PMC article. - Feather buds exert a polarizing activity when transplanted to chick limb buds.
Uchiyama K, Yanazawa M, Kuroiwa A, Kitamura K. Uchiyama K, et al. Dev Growth Differ. 1996 Dec;38(6):635-645. doi: 10.1046/j.1440-169X.1996.t01-5-00007.x. Dev Growth Differ. 1996. PMID: 37281919 - A Drosophila receptor-type tyrosine kinase (DFR1) acts as a fibroblast growth factor receptor in Xenopus embryos.
Yoshioka H, Ohuchi H, Ishimaru Y, Ishikawa T, Nohno T, Saigo K, Noji S. Yoshioka H, et al. Dev Growth Differ. 1996 Dec;38(6):617-624. doi: 10.1046/j.1440-169X.1996.t01-5-00005.x. Dev Growth Differ. 1996. PMID: 37281644
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources