Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function - PubMed (original) (raw)
. 1994 Oct 27;371(6500):762-7.
doi: 10.1038/371762a0.
Affiliations
- PMID: 7935836
- DOI: 10.1038/371762a0
Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function
A Pause et al. Nature. 1994.
Abstract
The cloning is described of two related human complementary DNAs encoding polypeptides that interact specifically with the translation initiation factor eIF-4E, which binds to the messenger RNA 5'-cap structure. Interaction of these proteins with eIF-4E inhibits translation but treatment of cells with insulin causes one of them to become hyperphosphorylated and dissociate from eIF-4E, thereby relieving the translational inhibition. The action of this new regulator of protein synthesis is therefore modulated by insulin, which acts to stimulate the overall rate of translation and promote cell growth.
Comment in
- Translation. Turned on by insulin.
Proud CG. Proud CG. Nature. 1994 Oct 27;371(6500):747-8. doi: 10.1038/371747a0. Nature. 1994. PMID: 7935831 No abstract available.
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