Study on the induction of spontaneous transmitter release at early nerve-muscle contacts in Xenopus cultures - PubMed (original) (raw)

Study on the induction of spontaneous transmitter release at early nerve-muscle contacts in Xenopus cultures

N Tabti et al. Neurosci Lett. 1994.

Abstract

During synaptogenesis, spontaneous acetylcholine release is rapidly induced by the contact of the growing neurite with the myocyte. Using Xenopus nerve-muscle co-cultures, we investigated the role of Ca2+ in the presynaptic mechanisms mediating this induction process. We found that Ca2+ influx is not necessary to induce spontaneous release and that an increase in cytosolic Ca2+ is not sufficient to trigger this release in the absence of the target cell.

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