Evolutionary relationships of lactate dehydrogenases (LDHs) from mammals, birds, an amphibian, fish, barley, and bacteria: LDH cDNA sequences from Xenopus, pig, and rat - PubMed (original) (raw)

Comparative Study

Evolutionary relationships of lactate dehydrogenases (LDHs) from mammals, birds, an amphibian, fish, barley, and bacteria: LDH cDNA sequences from Xenopus, pig, and rat

S Tsuji et al. Proc Natl Acad Sci U S A. 1994.

Abstract

The nucleotide sequences of the cDNAs encoding LDH (EC 1.1.1.27) subunits LDH-A (muscle), LDH-B (liver), and LDH-C (oocyte) from Xenopus laevis, LDH-A (muscle) and LDH-B (heart) from pig, and LDH-B (heart) and LDH-C (testis) from rat were determined. These seven newly deduced amino acid sequences and 22 other published LDH sequences, and three unpublished fish LDH-A sequences kindly provided by G. N. Somero and D. A. Powers, were used to construct the most parsimonious phylogenetic tree of these 32 LDH subunits from mammals, birds, an amphibian, fish, barley, and bacteria. There have been at least six LDH gene duplications among the vertebrates. The Xenopus LDH-A, LDH-B, and LDH-C subunits are most closely related to each other and then are more closely related to vertebrate LDH-B than LDH-A. Three fish LDH-As, as well as a single LDH of lamprey, also seem to be more related to vertebrate LDH-B than to land vertebrate LDH-A. The mammalian LDH-C (testis) subunit appears to have diverged very early, prior to the divergence of vertebrate LDH-A and LDH-B subunits, as reported previously.

PubMed Disclaimer

Similar articles

Cited by

References

    1. J Biol Chem. 1983 Jun 10;258(11):7029-32 - PubMed
    1. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):242-6 - PubMed
    1. Hoppe Seylers Z Physiol Chem. 1983 Jul;364(7):893-909 - PubMed
    1. Eur J Biochem. 1985 Feb 15;147(1):9-15 - PubMed
    1. Eur J Biochem. 1985 Jun 3;149(2):215-25 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources