Monitoring the partitioning of hepatic fatty acids in vivo: keeping track of control - PubMed (original) (raw)
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Monitoring the partitioning of hepatic fatty acids in vivo: keeping track of control
V A Zammit et al. Trends Biochem Sci. 1994 Aug.
Abstract
Noninvasive labelling of hepatic fatty acids in conscious, unrestrained rats shows how liver lipid metabolism responds acutely to physiological perturbations, such as the starved-to-refed transition. The speed with which the liver switches from fatty acid oxidation to esterification varies widely according to the requirement of the animal for continued synthesis of glucose 6-phosphate from three-carbon precursors. Ingestion of a meal also provides a strong signal for the diversion of fatty acids away from triacylglycerol synthesis and secretion, but insulin may only play an indirect role in this effect.
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