A mechanism for P-glycoprotein action in multidrug resistance: are we there yet? - PubMed (original) (raw)
Review
A mechanism for P-glycoprotein action in multidrug resistance: are we there yet?
S Ruetz et al. Trends Pharmacol Sci. 1994 Jul.
Abstract
Multidrug resistance is associated with the overexpression of P-glycoprotein, a membrane glycoprotein. The mechanism by which P-glycoprotein confers to cells the capacity to resist cytotoxic attack by structurally unrelated drugs has remained difficult to decipher. However, the recent functional expression of this group of proteins in the membrane of secretory vesicles from yeast mutants has allowed the systematic analysis of the parameters of drug transport by this protein. Proposed mechanisms of action of P-glycoprotein are discussed in this review by Stephan Ruetz and Philippe Gros.
Comment in
- Indirect mechanism of drug transport by P-glycoprotein.
Roepe PD. Roepe PD. Trends Pharmacol Sci. 1994 Dec;15(12):445-6. doi: 10.1016/0165-6147(94)90056-6. Trends Pharmacol Sci. 1994. PMID: 7886815 No abstract available.
Similar articles
- P-glycoprotein and multidrug resistance.
Gottesman MM, Pastan I, Ambudkar SV. Gottesman MM, et al. Curr Opin Genet Dev. 1996 Oct;6(5):610-7. doi: 10.1016/s0959-437x(96)80091-8. Curr Opin Genet Dev. 1996. PMID: 8939727 Review. - Structural and functional aspects of P-glycoproteins and related transport proteins.
Lepage P, Gros P. Lepage P, et al. Curr Opin Nephrol Hypertens. 1993 Sep;2(5):735-43. doi: 10.1097/00041552-199309000-00007. Curr Opin Nephrol Hypertens. 1993. PMID: 7522912 Review. - [Mechanism of resistance to antitumor agents--its involvement in blood-brain barrier].
Tsuruo T. Tsuruo T. Yakugaku Zasshi. 1995 Jul;115(7):513-22. doi: 10.1248/yakushi1947.115.7_513. Yakugaku Zasshi. 1995. PMID: 7562398 Review. Japanese. - Multidrug resistance in the chronic lymphoproliferative disorders.
Drain S, Catherwood MA, Alexander HD. Drain S, et al. Leuk Lymphoma. 2010 Oct;51(10):1793-804. doi: 10.3109/10428194.2010.500434. Leuk Lymphoma. 2010. PMID: 20615085 Review. - Hepatic canalicular membrane 4: expression of the multidrug resistance genes in the liver.
Silverman JA, Schrenk D. Silverman JA, et al. FASEB J. 1997 Apr;11(5):308-13. doi: 10.1096/fasebj.11.5.9141496. FASEB J. 1997. PMID: 9141496 Review.
Cited by
- High-dose extended-field radiotherapy plus chemotherapy improved survival in extranodal NK/T-cell lymphoma in a real-life setting: results from the multicenter T-Cell Brazil Project.
de Pádua Covas Lage LA, Machado PPF, Reichert CO, Miranda E, Culler HF, da Siqueira SAC, de Oliveira Costa R, Miyashiro DR, Sanches JA, Rocha V, Chiattone CS, Pereira J. de Pádua Covas Lage LA, et al. Sci Rep. 2022 Nov 29;12(1):20557. doi: 10.1038/s41598-022-25034-3. Sci Rep. 2022. PMID: 36446856 Free PMC article. - Curcumin: A Novel Way to Improve Quality of Life for Colorectal Cancer Patients?
Layos L, Martínez-Balibrea E, Ruiz de Porras V. Layos L, et al. Int J Mol Sci. 2022 Nov 14;23(22):14058. doi: 10.3390/ijms232214058. Int J Mol Sci. 2022. PMID: 36430537 Free PMC article. Review. - Enolase 1 stimulates glycolysis to promote chemoresistance in gastric cancer.
Qian X, Xu W, Xu J, Shi Q, Li J, Weng Y, Jiang Z, Feng L, Wang X, Zhou J, Jin H. Qian X, et al. Oncotarget. 2017 Jul 18;8(29):47691-47708. doi: 10.18632/oncotarget.17868. Oncotarget. 2017. PMID: 28548950 Free PMC article. - The Warburg effect and drug resistance.
Bhattacharya B, Mohd Omar MF, Soong R. Bhattacharya B, et al. Br J Pharmacol. 2016 Mar;173(6):970-9. doi: 10.1111/bph.13422. Epub 2016 Feb 18. Br J Pharmacol. 2016. PMID: 26750865 Free PMC article. Review. - ATP- and glutathione-dependent transport of chemotherapeutic drugs by the multidrug resistance protein MRP1.
Renes J, de Vries EG, Nienhuis EF, Jansen PL, Müller M. Renes J, et al. Br J Pharmacol. 1999 Feb;126(3):681-8. doi: 10.1038/sj.bjp.0702360. Br J Pharmacol. 1999. PMID: 10188979 Free PMC article.